Chemical profiling and cytotoxic activity of 150-year old original sample of Jerusalem Balsam.
Animals
Anti-Bacterial Agents
/ analysis
Anti-Inflammatory Agents
/ analysis
Antifungal Agents
/ analysis
Antineoplastic Agents, Phytogenic
/ analysis
Antioxidants
/ analysis
Balsams
/ chemistry
Benzaldehydes
/ analysis
Benzoic Acid
/ analysis
Cell Line, Tumor
Cell Survival
/ drug effects
Cinnamates
/ analysis
Dogs
Gas Chromatography-Mass Spectrometry
Humans
Mice
NIH 3T3 Cells
Phytochemicals
/ analysis
Sesquiterpenes
/ analysis
Volatile Organic Compounds
/ analysis
Cytotoxicity
Essential oils
Herbal formulation
Jerusalem Balsam
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
05
03
2019
revised:
11
12
2019
accepted:
06
02
2020
pubmed:
18
2
2020
medline:
1
12
2020
entrez:
17
2
2020
Statut:
ppublish
Résumé
Herbal formulations have been used in ethnomedicine and pharmacy around the world for thousands of years. One of them is Jerusalem Balsam (JB), which came into use in the seventeenth century. Today, people still produce and use it regularly as prophylactic supplement. JB has been widely used in Europe since the nineteenth century, as a remedy possessing antibacterial, antifungal and anti-inflammatory activities. The composition of the product was not known, although possible formulations were reported. In this study the original sample, which dated back to 1870, was investigated for chemical composition and cytotoxic activity. The obtained results were compared with results from more recently produced samples. Several tests were carried out, namely GC-MS, UPLC-PDA-Q-TOF-MS and MTT. Only the 150-year old sample showed a significant cytotoxic activity on cancer cell lines. At a concentration of 125 μg/mL after 72 h of incubation, the original sample inhibited almost 90% of cell metabolic activity, while contemporary samples showed none or little activity. None of the tested samples showed a significant impact on normal cells. These results may be attributed to the activities of benzoic acid and its derivatives, cinnamic acid derivatives, vanillin, group of sesquiterpenes and cembrene.
Identifiants
pubmed: 32061855
pii: S0278-6915(20)30071-5
doi: 10.1016/j.fct.2020.111183
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Inflammatory Agents
0
Antifungal Agents
0
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Balsams
0
Benzaldehydes
0
Cinnamates
0
Phytochemicals
0
Sesquiterpenes
0
Volatile Organic Compounds
0
Benzoic Acid
8SKN0B0MIM
vanillin
CHI530446X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111183Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.