The role of Chinese herbal medicine in the management of adverse drug reactions of leflunomide in treating rheumatoid arthritis.
Adverse drug reactions
Chinese herbal medicine
Leflunomide
Rheumatoid arthritis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
19
07
2019
revised:
30
10
2019
accepted:
17
11
2019
pubmed:
18
2
2020
medline:
12
5
2020
entrez:
17
2
2020
Statut:
ppublish
Résumé
The high discontinuation rate in RA patients who use LEF might be attributed to their intolerance rather than irresponsibility. The concomitant administration of Leflunomide (LEF) with Chinese herbal medicine (CHM) provides a potential solution to preventing the adverse drug reactions (ADRs) induced by LEF during the treatment of rheumatoid arthritis (RA). To investigate whether co-administration of LEF with CHM could bring in both increased therapeutic outcomes and reduced ADRs due to the framework of treatment at the level of entire body. The mechanism of LEF in RA treatment and the ADRs it induced was introduced based on recent papers. Reported clinical examples of CHM concurrent use with LEF was revealed to provide more evidence. The management of the ADRs caused by LEF was suggested by current researches on the concomitant therapy of CHM with LEF. The active ingredients, compounds and medicinal herbs all demonstrated properties in relieving toxicities and reducing ADRs when used with LEF and reported in several clinical cases. The wide application of concurrent use of CHM with LEF is however hindered by the complex pathogenesis of RA which requires further scientific grounds for diagnosis and treatment. This review introduced that the adoption of CHM is emerging as a novel strategy for the management of ADRs caused by LEF.
Sections du résumé
BACKGROUND
BACKGROUND
The high discontinuation rate in RA patients who use LEF might be attributed to their intolerance rather than irresponsibility. The concomitant administration of Leflunomide (LEF) with Chinese herbal medicine (CHM) provides a potential solution to preventing the adverse drug reactions (ADRs) induced by LEF during the treatment of rheumatoid arthritis (RA).
PURPOSE
OBJECTIVE
To investigate whether co-administration of LEF with CHM could bring in both increased therapeutic outcomes and reduced ADRs due to the framework of treatment at the level of entire body.
STUDY DESIGN
METHODS
The mechanism of LEF in RA treatment and the ADRs it induced was introduced based on recent papers. Reported clinical examples of CHM concurrent use with LEF was revealed to provide more evidence. The management of the ADRs caused by LEF was suggested by current researches on the concomitant therapy of CHM with LEF.
RESULTS
RESULTS
The active ingredients, compounds and medicinal herbs all demonstrated properties in relieving toxicities and reducing ADRs when used with LEF and reported in several clinical cases. The wide application of concurrent use of CHM with LEF is however hindered by the complex pathogenesis of RA which requires further scientific grounds for diagnosis and treatment.
CONCLUSION
CONCLUSIONS
This review introduced that the adoption of CHM is emerging as a novel strategy for the management of ADRs caused by LEF.
Identifiants
pubmed: 32062477
pii: S0944-7113(19)30452-0
doi: 10.1016/j.phymed.2019.153136
pii:
doi:
Substances chimiques
Antirheumatic Agents
0
Drugs, Chinese Herbal
0
Leflunomide
G162GK9U4W
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
153136Informations de copyright
Copyright © 2019. Published by Elsevier GmbH.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.