Effects of Diets Enriched in Linseed and Fish Oil on the Expression Pattern of Toll-Like Receptors 4 and Proinflammatory Cytokines on Gonadal Axis and Reproductive Organs in Rabbit Buck.
Animal Feed
Animals
Diet
Epididymis
/ metabolism
Fatty Acids, Omega-3
/ metabolism
Fish Oils
/ pharmacology
Hypothalamus
/ metabolism
Inflammation
/ metabolism
Interleukin-1beta
/ metabolism
Linseed Oil
/ pharmacology
Male
Pituitary Gland
/ cytology
Rabbits
Seminal Vesicles
/ metabolism
Spermatozoa
/ metabolism
Testis
/ cytology
Toll-Like Receptor 4
/ genetics
Tumor Necrosis Factor-alpha
/ metabolism
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
09
2019
revised:
11
12
2019
accepted:
20
12
2019
entrez:
18
2
2020
pubmed:
18
2
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Infections of the genital tract can perturb the fertility in humans and animals. Pathogen recognition and activation of innate immunity onset through the pattern recognition receptor activation, such as Toll-like receptor 4 (TLR4), leading to the production of proinflammatory cytokines and mediators. TLR4 is expressed both on leukocytes and nonimmune cells. Rabbit TLR4 shows great similarity to its human counterpart. Moreover, the TLR4 signalling pathway could be modulated by long-chain polyunsaturated fatty acids (LC-PUFA). The objectives of this study were (i) to determine the expression levels of TLR4 and proinflammatory cytokines in the reproductive hypothalamic-gonadal axis of the male rabbit and (ii) to evaluate if the n-3 PUFA-enriched diets can modify their expression levels in the tissues and LC-PUFA profiles in seminal plasma. Fifteen rabbit bucks (
Identifiants
pubmed: 32064024
doi: 10.1155/2020/4327470
pmc: PMC6996712
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Fish Oils
0
Interleukin-1beta
0
Toll-Like Receptor 4
0
Tumor Necrosis Factor-alpha
0
Linseed Oil
8001-26-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4327470Informations de copyright
Copyright © 2020 Laura Menchetti et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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