Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.


Journal

Journal of visualized experiments : JoVE
ISSN: 1940-087X
Titre abrégé: J Vis Exp
Pays: United States
ID NLM: 101313252

Informations de publication

Date de publication:
22 01 2020
Historique:
entrez: 18 2 2020
pubmed: 18 2 2020
medline: 2 9 2020
Statut: epublish

Résumé

Mammalian sperm acquire fertilization capacity in the female reproductive tract in a process known as capacitation. Capacitation-associated processes require energy. There remains an ongoing debate about the sources generating the ATP which fuels sperm progressive motility, capacitation, hyperactivation, and acrosome reaction. Here, we describe the application of an extracellular flux analyzer as a tool to analyze changes in energy metabolism during mouse sperm capacitation. Using H

Identifiants

pubmed: 32065141
doi: 10.3791/60815
doi:

Types de publication

Journal Article Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Melanie Balbach (M)

Department of Pharmacology, Weill Cornell Medical College; meb2023@med.cornell.edu.

Jochen Buck (J)

Department of Pharmacology, Weill Cornell Medical College.

Lonny R Levin (LR)

Department of Pharmacology, Weill Cornell Medical College.

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Classifications MeSH