Association between interferon lambda 3 rs12979860 polymorphism and clinical outcome in dengue virus-infected children.
children
dengue
interferon
polymorphism
Journal
International journal of immunogenetics
ISSN: 1744-313X
Titre abrégé: Int J Immunogenet
Pays: England
ID NLM: 101232337
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
25
04
2018
revised:
26
12
2019
accepted:
13
01
2020
pubmed:
18
2
2020
medline:
10
6
2021
entrez:
18
2
2020
Statut:
ppublish
Résumé
Single nucleotide polymorphisms (SNPs) in immune-related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between IFNL3 gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue-related symptoms (aged 1-15 years) admitted at a public hospital in Northeast Brazil were invited to participate. The association between rs12979860 polymorphism and dengue classification and clinical signs and symptoms were analysed. A total of 206 DENV-infected children were included: 53.4% of the infections were classified as severe dengue. The T allele carriers had higher risk of developing severe dengue when compared to CC genotype carriers (OR: 1.81; 95% CI: 0.98-3.32 p = .054). The T allele carriers also showed longer fever episodes when compared to patients with the CC genotype (OR: 1.90; 95%CI: 1.07-3.38; p = .027). On the other hand, the ones carrying the CT/TT genotype had 70% lower chance of developing thrombocytopenia when compared to those with the CC genotype (OR: 0.30; 95%CI: 0.08-0.88; p = .042). Our findings demonstrated that the T allele carriers of the IFNL3 gene had higher risk of developing severe dengue, suggesting a link between IFN-λ expression and DENV immunopathogenesis.
Substances chimiques
interferon-lambda, human
0
Interferons
9008-11-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-358Subventions
Organisme : Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco
ID : APQ-0296-4.01/08
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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