ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin

Acetylation Acetyltransferases / physiology CCCTC-Binding Factor / physiology Carrier Proteins / genetics Cell Cycle Proteins / metabolism Chromatin / metabolism Chromosomal Proteins, Non-Histone / metabolism Computer Simulation G1 Phase Genome, Human Humans Nuclear Proteins / genetics Protein Binding Proto-Oncogene Proteins / genetics Cohesins
CTCF TADs cell biology chromatin structure chromosomes cohesin gene expression genome organization human loops

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
17 02 2020
Historique:
received: 22 09 2019
accepted: 10 02 2020
pubmed: 18 2 2020
medline: 27 4 2021
entrez: 18 2 2020
Statut: epublish

Résumé

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes

Identifiants

DOI: 10.7554/eLife.52091 PMID: 32065581 PMC: PMC7054000
pubmed: 32065581
doi: 10.7554/eLife.52091
pii: 52091
pmc: PMC7054000
doi:
pii:

Substances chimiques

CCCTC-Binding Factor 0
CTCF protein, human 0
Carrier Proteins 0
Cell Cycle Proteins 0
Chromatin 0
Chromosomal Proteins, Non-Histone 0
Nuclear Proteins 0
Proto-Oncogene Proteins 0
WAPL protein, human 0
Acetyltransferases EC 2.3.1.-
ESCO1 protein, human EC 2.3.1.-

Banques de données

GEO
['GSE138405', 'GSE102884']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : U01 HL130010
Pays : United States
Organisme : Austrian Science Fund
ID : SFB F34
Organisme : Austrian Science Fund by ERA-CAPS
ID : 3686
Organisme : Austrian Research Promotion Agency
ID : FFG-852936
Organisme : NIH Clinical Center
ID : 5UM1HG009375-03
Organisme : Vienna Science and Technology Fund
ID : WWTF LS09-13
Organisme : European Research Council
ID : 340152 DEVOCHROMO
Pays : International
Organisme : Human Frontier Science Program
ID : RGP0057/2018
Organisme : The Austrian Science Fund
ID : SFB F34
Organisme : Medical Research Council
ID : MR/T016787/1
Pays : United Kingdom
Organisme : NIH Clinical Center
ID : 5U01HL130010-05
Organisme : Österreichische Forschungsförderungsgesellschaft
ID : FFG-852936
Organisme : EMBO
ID : ALTF 1335-2016
Organisme : Human Frontier Science Program
ID : LT001527/2017
Organisme : NHGRI NIH HHS
ID : UM1 HG009375
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J004480/1
Pays : United Kingdom
Organisme : Horizon 2020 Framework Programme
ID : EPIC-XS 823839
Organisme : The Austrian Science Fund
ID : Z196-B20
Organisme : The European community's Seventh Frame- work Programme
ID : FP7/2007-2013 241548
Organisme : H2020 European Research Council
ID : 693949
Organisme : Seventh Framework Programme
ID : FP7/2007-2013 241548
Organisme : National Science Foundation
ID : PHY-1427654

Informations de copyright

© 2020, Wutz et al.

Déclaration de conflit d'intérêts

GW, RL, BS, RS, KN, BP, AS, WT, CV, MI, SS, Pv, XH, GD, ER, KM, ID, PF, EL, JP No competing interests declared

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Auteurs

Gordana Wutz (G)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
ORCID: 0000-0002-6842-0795

Rene Ladurner (R)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Brian Glenn St Hilaire (BG)

The Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Center for Theoretical Biological Physics, Rice University, Houston, United States.

Roman R Stocsits (RR)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Kota Nagasaka (K)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
ORCID: 0000-0003-0765-638X

Benoit Pignard (B)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Adrian Sanborn (A)

The Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Department of Computer Science, Stanford University, Stanford, United States.

Wen Tang (W)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Csilla Várnai (C)

Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom.

Miroslav P Ivanov (MP)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
ORCID: 0000-0001-9352-0969

Stefan Schoenfelder (S)

Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
ORCID: 0000-0002-3200-8133

Petra van der Lelij (P)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Xingfan Huang (X)

The Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Departments of Computer Science and Computational and Applied Mathematics, Rice University, Houston, United States.
Departments of Computer Science and Genome Sciences, University of Washington, Seattle, United States.

Gerhard Dürnberger (G)

Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.

Elisabeth Roitinger (E)

Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.

Karl Mechtler (K)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
Institute of Molecular Biotechnology, Vienna Biocenter (VBC), Vienna, Austria.

Iain Finley Davidson (IF)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.

Peter Fraser (P)

Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
Department of Biological Science, Florida State University, Tallahassee, United States.

Erez Lieberman-Aiden (E)

The Center for Genome Architecture, Baylor College of Medicine, Houston, United States.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Center for Theoretical Biological Physics, Rice University, Houston, United States.
Departments of Computer Science and Computational and Applied Mathematics, Rice University, Houston, United States.
Broad Institute of MIT and Harvard, Cambridge, United States.
Shanghai Institute for Advanced Immunochemical Studies, Shanghai Tech University, Shanghai, China.

Jan-Michael Peters (JM)

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
ORCID: 0000-0003-2820-3195

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Acylation › Acétylation › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur de liaison à la séquence CCCTC › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Interphase › Phase G1 › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome humain › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › ESCO1 and CTCF enable formation of long...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › ESCO1 and CTCF enable formation of long...