Genetic associations with clozapine-induced myocarditis in patients with schizophrenia.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
27 01 2020
27 01 2020
Historique:
received:
03
06
2019
accepted:
30
12
2019
revised:
09
12
2019
entrez:
19
2
2020
pubmed:
19
2
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Clozapine is the most effective antipsychotic drug for schizophrenia, yet it can cause life-threatening adverse drug reactions, including myocarditis. The aim of this study was to determine whether schizophrenia patients with clozapine-induced myocarditis have a genetic predisposition compared with clozapine-tolerant controls. We measured different types of genetic variation, including genome-wide single-nucleotide polymorphisms (SNPs), coding variants that alter protein expression, and variable forms of human leucocyte antigen (HLA) genes, alongside traditional clinical risk factors in 42 cases and 67 controls. We calculated a polygenic risk score (PRS) based on variation at 96 different genetic sites, to estimate the genetic liability to clozapine-induced myocarditis. Our genome-wide association analysis identified four SNPs suggestive of increased myocarditis risk (P < 1 × 10
Identifiants
pubmed: 32066683
doi: 10.1038/s41398-020-0722-0
pii: 10.1038/s41398-020-0722-0
pmc: PMC7026069
doi:
Substances chimiques
Antipsychotic Agents
0
Clozapine
J60AR2IKIC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37Subventions
Organisme : Medical Research Council
ID : MR/L006758/1
Pays : United Kingdom
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