Muscle Injury Induces Postoperative Cognitive Dysfunction.

Aging / pathology Animals Brain / pathology Brain-Derived Neurotrophic Factor / metabolism CX3C Chemokine Receptor 1 / genetics Cytokines / metabolism Disease Models, Animal Hippocampus / injuries Humans Male Mice Microglia / pathology Muscle, Skeletal / injuries Nerve Growth Factor / metabolism Postoperative Cognitive Complications / etiology Postoperative Complications / etiology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
17 02 2020
Historique:
received: 23 08 2019
accepted: 31 01 2020
entrez: 19 2 2020
pubmed: 19 2 2020
medline: 13 11 2020
Statut: epublish

Résumé

Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1

Identifiants

DOI: 10.1038/s41598-020-59639-3 PMID: 32066806 PMC: PMC7026159
pubmed: 32066806
doi: 10.1038/s41598-020-59639-3
pii: 10.1038/s41598-020-59639-3
pmc: PMC7026159
doi:

Substances chimiques

Bdnf protein, mouse 0
Brain-Derived Neurotrophic Factor 0
CX3C Chemokine Receptor 1 0
Cx3cr1 protein, mouse 0
Cytokines 0
Nerve Growth Factor 9061-61-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2768

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Auteurs

Lorna Guéniot (L)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.
Direction Générale de l'Armement, Ministère des Armées, Paris, France.
Paris Descartes University, ED Bio-SPC, Sorbonne Paris Cité, Paris, France.

Victoria Lepere (V)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.
Multidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris, France.
Polyvalent Surgical Resuscitation, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.

Gabriela Ferreira De Medeiros (GF)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.

Anne Danckaert (A)

Institut Pasteur, UtechS Photonic BioImaging (Imagopole), C2RT, Paris, France.
ORCID: 0000-0001-8984-643X

Patricia Flamant (P)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.

Marine Le Dudal (M)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.

Olivier Langeron (O)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.
Department of Anesthesia and Critical Care, Hôpitaux Universitaires Henri Mondor-Créteil-Assistance Publique Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.

Pierre L Goossens (PL)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.

Fabrice Chrétien (F)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France.
Paris Descartes University, ED Bio-SPC, Sorbonne Paris Cité, Paris, France.
Service de Neuropathologie, Centre Hospitalier Sainte Anne, GHU Paris Psychiatrie Neuroscience, Paris, France.

Grégory Jouvion (G)

Institut Pasteur, Experimental Neuropathology Unit, Paris, France. gregory.jouvion@pasteur.fr.
Sorbonne Université, INSERM, Pathophysiology of pediatric genetic diseases, Assistance Publique-Hôpitaux de Paris, Hôpital Armand-Trousseau, UF Génétique moléculaire, Paris, France. gregory.jouvion@pasteur.fr.
ORCID: 0000-0003-0188-2554

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteur-1 de la chimiokine CX3C › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur de croissance nerveuse › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Complications post-opératoires cognitives › Muscle Injury Induces Postoperative Cognitive...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Muscle Injury Induces Postoperative Cognitive...