Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis.
Animals
B-Lymphocytes
/ immunology
Cell Proliferation
Energy Metabolism
Fatty Acids
/ metabolism
Fatty Acids, Nonesterified
/ metabolism
Gene Expression
Germinal Center
/ cytology
Glucose
/ metabolism
Glycolysis
/ genetics
In Vitro Techniques
Metabolome
Mice
Mice, Inbred BALB C
Mice, Knockout
Oxidation-Reduction
Oxidative Phosphorylation
Oxygen Consumption
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
08
04
2019
accepted:
13
01
2020
pubmed:
19
2
2020
medline:
21
4
2020
entrez:
19
2
2020
Statut:
ppublish
Résumé
Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are exceptional among proliferating B and T cells, as they actively oxidize fatty acids (FAs) and conduct minimal glycolysis. In vitro, GCBCs had a very low glycolytic extracellular acidification rate but consumed oxygen in response to FAs. [
Identifiants
pubmed: 32066950
doi: 10.1038/s41590-020-0598-4
pii: 10.1038/s41590-020-0598-4
pmc: PMC7112716
mid: NIHMS1549638
doi:
Substances chimiques
Fatty Acids
0
Fatty Acids, Nonesterified
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
331-342Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK114012
Pays : United States
Organisme : NIH HHS
ID : S10 OD011925
Pays : United States
Organisme : NIH HHS
ID : S10 OD023402
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105018
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI089443
Pays : United States
Organisme : NIH HHS
ID : S10 OD019942
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI043603
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
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