Dose planning variations related to delineation variations in MRI-guided brachytherapy for locally advanced cervical cancer.
Brachytherapy
Cervical cancer
Contouring
Delineation uncertainties
Image-guided adaptive
MRI
Planning variations
Journal
Brachytherapy
ISSN: 1873-1449
Titre abrégé: Brachytherapy
Pays: United States
ID NLM: 101137600
Informations de publication
Date de publication:
Historique:
received:
24
10
2019
revised:
02
01
2020
accepted:
02
01
2020
pubmed:
19
2
2020
medline:
29
12
2020
entrez:
19
2
2020
Statut:
ppublish
Résumé
To examine the variability in prescribed dose due to contouring variations in intracavitary image-guided adaptive brachytherapy for cervical cancer. To identify correlations between dosimetric outcomes and delineation uncertainty metrics. A data set from an EMBRACE sub-study on contouring uncertainties was used, consisting of magnetic resonance images of six patients with cervical cancer delineated by 10 experienced observers (target volumes and organs at risk). Two gold standard contours were generated, an expert consensus and the simultaneous truth and performance level estimation. Plans were individually optimised to all of the contour sets (12 in total). Plans were applied to the gold standard contour sets, and dose volume histogram parameters including D There is a dosimetric variability between observers, patients and the gold standard contour used for analysis. Approximately 3 Gy D This study highlights the dosimetric differences interobserver uncertainty in contouring can have for cervical cancer brachytherapy. The importance of carefully choosing a gold standard from which to benchmark is reiterated.
Identifiants
pubmed: 32067884
pii: S1538-4721(20)30002-7
doi: 10.1016/j.brachy.2020.01.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
146-153Informations de copyright
Copyright © 2020 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.