Characterization of the inflammatory features of central centrifugal cicatricial alopecia.
CD4 T-cells
Langerhans cells
central centrifugal
cicatricial alopecia
scarring alopecia
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
01
10
2019
revised:
26
12
2019
accepted:
03
01
2020
pubmed:
19
2
2020
medline:
4
3
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that primarily affects women of African descent. Although histopathological features of CCCA have been described, the pathophysiology of this disease remains unclear. To better understand the components of CCCA pathophysiology, we evaluated the composition of the inflammatory infiltrate, the distribution of Langerhans cells (LCs), and the relationship between fibrosis and perifollicular vessel distribution. Our data indicate that CCCA is associated with a CD4-predominant T-cell infiltrate with increased LCs extending into the lower hair follicle. Fibroplasia associated with follicular scarring displaces blood vessels away from the outer root sheath epithelium. These data indicate that CCCA is an inflammatory scarring alopecia with unique pathophysiologic features that differentiate it from other lymphocytic scarring processes.
Identifiants
pubmed: 32068905
doi: 10.1111/cup.13666
pmc: PMC7401378
mid: NIHMS1613096
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-534Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR069589
Pays : United States
Organisme : CSR NIH HHS
ID : P30-AR069589
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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