Investigation of Within-Tablet Dynamics for Extended Release of a Poorly Soluble Basic Drug from Hydrophilic Matrix Tablets Using ATR-FTIR Imaging.
Delayed-Action Preparations
/ chemistry
Drug Liberation
/ drug effects
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Hypromellose Derivatives
/ chemistry
Kinetics
Osmolar Concentration
Polymers
/ chemistry
Solubility
/ drug effects
Spectroscopy, Fourier Transform Infrared
/ methods
Tablets
/ chemistry
HPMC
extended release
gel layer
itraconazole
poorly soluble drug
real time imaging
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
06 04 2020
06 04 2020
Historique:
pubmed:
19
2
2020
medline:
29
5
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
Hydrophilic matrices are an effective option for oral controlled release but can face challenges in terms of bioavailability and efficacy when used in conjunction with poorly soluble, weakly basic drugs. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) imaging provides dynamic information relating to the location and chemical nature of both the sustained release matrix and the active pharmaceutical ingredient (API) during hydration/dissolution. In this study, we have identified a model system combining itraconazole (IT), a poorly soluble, weakly basic API that has p
Identifiants
pubmed: 32069060
doi: 10.1021/acs.molpharmaceut.9b01063
doi:
Substances chimiques
Delayed-Action Preparations
0
Polymers
0
Tablets
0
Hypromellose Derivatives
3NXW29V3WO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM