Oxygen therapy in patients with ST elevation myocardial infarction based on the culprit vessel: results from the randomized controlled SOCCER trial.
Aged
Comorbidity
Coronary Vessels
/ pathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen Inhalation Therapy
/ methods
Percutaneous Coronary Intervention
/ methods
ST Elevation Myocardial Infarction
/ pathology
Severity of Illness Index
Single-Blind Method
Sweden
Troponin T
/ blood
Cardiac magnetic resonance imaging
High-sensitive troponin T
Infarct size
Left anterior descending artery
Myocardial infarction
Myocardial salvage index
Myocardium at risk
Oxygen
Randomized controlled trials
ST elevation myocardial infarction
Journal
BMC emergency medicine
ISSN: 1471-227X
Titre abrégé: BMC Emerg Med
Pays: England
ID NLM: 100968543
Informations de publication
Date de publication:
18 02 2020
18 02 2020
Historique:
received:
12
06
2019
accepted:
10
02
2020
entrez:
20
2
2020
pubmed:
20
2
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Oxygen (O This was a two-center, investigator-initiated, single-blind, parallel-group, randomized controlled trial at the Skåne university hospital, Sweden. A simple computer-generated randomization was used. Patients were either randomized to standard care with O A total of 229 patients were assessed for eligibility, and 160 of them were randomized to the oxygen or air arm. Because of primarily technical problems with the CMRI, 95 patients were included in the final analyses; 46 in the oxygen arm and 49 in the air arm. There were no significant differences between patients with LAD and Non-LAD as culprit vessel with regard to their allocation (oxygen or air) with regards to MSI, MaR, IS and hs-cTnT. The results indicate that the location of the culprit vessel has probably no effect on the role of supplemental oxygen therapy in STEMI patients. Swedish Medical Products Agency (EudraCT No. 2011-001452-11) and ClinicalTrials.gov Identifier (NCT01423929).
Sections du résumé
BACKGROUND
Oxygen (O
METHODS
This was a two-center, investigator-initiated, single-blind, parallel-group, randomized controlled trial at the Skåne university hospital, Sweden. A simple computer-generated randomization was used. Patients were either randomized to standard care with O
RESULTS
A total of 229 patients were assessed for eligibility, and 160 of them were randomized to the oxygen or air arm. Because of primarily technical problems with the CMRI, 95 patients were included in the final analyses; 46 in the oxygen arm and 49 in the air arm. There were no significant differences between patients with LAD and Non-LAD as culprit vessel with regard to their allocation (oxygen or air) with regards to MSI, MaR, IS and hs-cTnT.
CONCLUSION
The results indicate that the location of the culprit vessel has probably no effect on the role of supplemental oxygen therapy in STEMI patients.
TRIAL REGISTRATION
Swedish Medical Products Agency (EudraCT No. 2011-001452-11) and ClinicalTrials.gov Identifier (NCT01423929).
Identifiants
pubmed: 32070283
doi: 10.1186/s12873-020-00309-y
pii: 10.1186/s12873-020-00309-y
pmc: PMC7027294
doi:
Substances chimiques
Troponin T
0
Banques de données
ClinicalTrials.gov
['NCT01423929']
EudraCT
['2011-001452-11']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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