AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.

Animals Anti-Bacterial Agents / chemistry Bacteria / drug effects Biofilms / drug effects Disease Models, Animal Down-Regulation Drug Resistance, Bacterial / drug effects Edetic Acid / chemistry Lung Diseases / drug therapy Metabolic Networks and Pathways Mice Nitrites / chemistry Pseudomonas aeruginosa / drug effects Sodium Nitrite / pharmacology

EDTA antibiotic resistance bactericidal biofilm sodium nitrite

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
03 03 2020

Historique:

pubmed: 20 2 2020

medline: 1 7 2020

entrez: 20 2 2020

Statut: ppublish

Résumé

Antibiotic-resistant superbug bacteria represent a global health problem with no imminent solutions. Here we demonstrate that the combination (termed AB569) of acidified nitrite (A-NO

Identifiants

DOI: 10.1073/pnas.1911927117 PMID: 32071223 PMC: PMC7060718

pubmed: 32071223

pii: 1911927117

doi: 10.1073/pnas.1911927117

pmc: PMC7060718

doi:

Substances chimiques

Anti-Bacterial Agents 0

Nitrites 0

Edetic Acid 9G34HU7RV0

Sodium Nitrite M0KG633D4F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

4921-4930

Subventions

Organisme : NHLBI NIH HHS

ID : U24 HL148865

Pays : United States

Déclaration de conflit d'intérêts

Competing interest statement: D.J.H. is a lead scientist for Arch Biopartners and has a US patent on AB569 (9,925,206) issued on March 27, 2019. D.A.M. is a cofounder and Chief Science Officer for Arch Biopartners. Arch Biopartners owns an exclusive option to license with the University of Cincinnati any patents regarding AB569.

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