Volume de-escalation in radiation therapy: state of the art and new perspectives.
Breast cancer
Head and neck cancer
Hodgkin’s lymphoma
Pancreatic cancer
Stereotactic body radiotherapy
Target volume de-escalation
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
17
01
2020
accepted:
10
02
2020
pubmed:
20
2
2020
medline:
4
4
2020
entrez:
20
2
2020
Statut:
ppublish
Résumé
New RT techniques and data emerging from follow-up for several tumor sites suggest that treatment volume de-escalation may permit to minimize therapy-related side effects and/or obtain better clinical outcomes. Here, we summarize the main evidence about volume de-escalation in RT. The relevant literature from PubMed was reviewed in this article. The ClinicalTrials.gov database was searched for clinical trials related to the specific topic. In Lymphoma, large-volume techniques (extended- and involved-field RT) are being successfully replaced by involved-site RT and involved-node RT. In head and neck carcinoma, spare a part of elective neck is controversial. In early breast cancer, partial breast irradiation has been established as a treatment option in low-risk patients. In pancreatic cancer stereotactic body radiotherapy may be used to dose escalation. Stereotactic radiosurgery should be the treatment choice for patients with oligometastatic brain disease and a life expectancy of more than 3 months, and it should be considered an alternative to WBRT for patients with multiple brain metastases. Further clinical trials are necessary to improve the identification of suitable patient cohorts and the extent of possible volume de-escalation that does not compromise tumor control.
Identifiants
pubmed: 32072318
doi: 10.1007/s00432-020-03152-7
pii: 10.1007/s00432-020-03152-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
909-924Références
Al-Mamgani A, van Rooij P, Fransen D, Levendag P (2013) Unilateral neck irradiation for well-lateralized oropharyngeal cancer. Radiother Oncol 106:69–73. https://doi.org/10.1016/j.radonc.2012.12.006
doi: 10.1016/j.radonc.2012.12.006
pubmed: 23324589
pmcid: 23324589
Al-Mamgani A et al (2017) Contralateral regional recurrence after elective unilateral neck irradiation in oropharyngeal carcinoma: a literature-based critical review. Cancer Treat Rev 59:102–108. https://doi.org/10.1016/j.ctrv.2017.07.004
doi: 10.1016/j.ctrv.2017.07.004
pubmed: 28779635
pmcid: 28779635
Alongi F et al (2019) First experience and clinical results using a new non-coplanar mono-isocenter technique (HyperArc) for Linac-based VMAT radiosurgery in brain metastases. J Cancer Res Clin Oncol 145:193–200. https://doi.org/10.1007/s00432-018-2781-7
doi: 10.1007/s00432-018-2781-7
pubmed: 30382369
pmcid: 30382369
Andre MPE et al (2017) Early positron emission tomography response-adapted treatment in stage I and Ii Hodgkin lymphoma: final results of the randomized EORTC/LYSA/FIL H10 Trial. J Clin Oncol 35:1786–1794. https://doi.org/10.1200/JCO.2016.68.6394
doi: 10.1200/JCO.2016.68.6394
pubmed: 28291393
pmcid: 28291393
Andrews DW et al (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363:1665–1672. https://doi.org/10.1016/S0140-6736(04)16250-8
doi: 10.1016/S0140-6736(04)16250-8
pubmed: 15158627
pmcid: 15158627
Ang KK et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35. https://doi.org/10.1056/NEJMoa0912217
doi: 10.1056/NEJMoa0912217
pubmed: 20530316
pmcid: 20530316
Aoyama H et al (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA J Am Med Assoc 295:2483–2491. https://doi.org/10.1001/jama.295.21.2483
doi: 10.1001/jama.295.21.2483
Baker S, Verduijn G, Petit S, Nuyttens JJ, Sewnaik A, van der Lugt A, Heemsbergen WD (2019) Locoregional failures and their relation to radiation fields following stereotactic body radiotherapy boost for oropharyngeal squamous cell carcinoma. Head Neck 41:1622–1631. https://doi.org/10.1002/hed.25587
doi: 10.1002/hed.25587
pubmed: 30636180
pmcid: 30636180
Barrington SF et al. (2014) Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group. J Clin Oncol 32:3048–3058 doi:10.1200/JCO.2013.53.5229
Bhatnagar AK, Flickinger JC, Kondziolka D, Lunsford LD (2006) Stereotactic radiosurgery for four or more intracranial metastases. Int J Radiat Oncol Biol Phys 64:898–903. https://doi.org/10.1016/j.ijrobp.2005.08.035
doi: 10.1016/j.ijrobp.2005.08.035
pubmed: 16338097
Bittner MI, Grosu AL, Brunner TB (2015) Comparison of toxicity after IMRT and 3D-conformal radiotherapy for patients with pancreatic cancer - a systematic review. Radiother Oncol 114:117–121. https://doi.org/10.1016/j.radonc.2014.11.043
doi: 10.1016/j.radonc.2014.11.043
pubmed: 25497876
Bottcher A et al (2017) A novel classification scheme for advanced laryngeal cancer midline involvement: implications for the contralateral neck. J Cancer Res Clin Oncol 143:1605–1612. https://doi.org/10.1007/s00432-017-2419-1
doi: 10.1007/s00432-017-2419-1
pubmed: 28396948
Brown PD et al (2016) Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA J Am Med Assoc 316:401–409. https://doi.org/10.1001/jama.2016.9839
doi: 10.1001/jama.2016.9839
Brown PD, Ahluwalia MS, Khan OH, Asher AL, Wefel JS, Gondi V (2018) Whole-brain radiotherapy for brain metastases: evolution or revolution? J Clin Oncol 36:483–491. https://doi.org/10.1200/JCO.2017.75.9589
doi: 10.1200/JCO.2017.75.9589
pubmed: 29272161
Buckley JG, MacLennan K (2000) Cervical node metastases in laryngeal and hypopharyngeal cancer: a prospective analysis of prevalence and distribution. Head Neck 22:380–385. https://doi.org/10.1002/1097-0347(200007)22:4%3c380:aid-hed11%3e3.0.co;2-e
doi: 10.1002/1097-0347(200007)22:4%3c380::aid-hed11%3e3.0.co;2-e
pubmed: 10862022
Burr AR, Harari PM, Ko HC, Bruce JY, Kimple RJ, Witek ME (2019) Reducing radiotherapy target volume expansion for patients with HPV-associated oropharyngeal cancer. Oral Oncol 92:52–56. https://doi.org/10.1016/j.oraloncology.2019.03.013
doi: 10.1016/j.oraloncology.2019.03.013
pubmed: 31010623
Campbell BA, Voss N, Pickles T, Morris J, Gascoyne RD, Savage KJ, Connors JM (2008) Involved-nodal radiation therapy as a component of combination therapy for limited-stage Hodgkin's lymphoma: a question of field size. J Clin Oncol 26:5170–5174. https://doi.org/10.1200/JCO.2007.15.1001
doi: 10.1200/JCO.2007.15.1001
pubmed: 18838714
Chang DT et al (2009) Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas. Cancer 115:665–672. https://doi.org/10.1002/cncr.24059
doi: 10.1002/cncr.24059
pubmed: 19117351
Chang EL et al (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037–1044. https://doi.org/10.1016/S1470-2045(09)70263-3
doi: 10.1016/S1470-2045(09)70263-3
pubmed: 19801201
Chang WS, Kim HY, Chang JW, Park YG, Chang JH (2010) Analysis of radiosurgical results in patients with brain metastases according to the number of brain lesions: is stereotactic radiosurgery effective for multiple brain metastases? J Neurosurg 113(Suppl):73–78. https://doi.org/10.3171/2010.8.GKS10994
doi: 10.3171/2010.8.GKS10994
pubmed: 21121789
Chin RI et al (2017) Comparison of unilateral versus bilateral intensity-modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil. Cancer 123:4594–4607. https://doi.org/10.1002/cncr.30931
doi: 10.1002/cncr.30931
pubmed: 28881377
Chow JM, Levin BC, Krivit JS, Applebaum EL (1989) Radiotherapy or surgery for subclinical cervical node metastases. Archives of Otolaryngol Head Neck Surg 115:981–984. https://doi.org/10.1001/archotol.1989.01860320091025
doi: 10.1001/archotol.1989.01860320091025
Chronowski GM et al (2012) Unilateral radiotherapy for the treatment of tonsil cancer. Int J Radiat Oncol Biol Phys 83:204–209. https://doi.org/10.1016/j.ijrobp.2011.06.1975
doi: 10.1016/j.ijrobp.2011.06.1975
pubmed: 22019242
Chuong MD et al (2013) Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated. Int J Radiat Oncol Biol Phys 86:516–522. https://doi.org/10.1016/j.ijrobp.2013.02.022
doi: 10.1016/j.ijrobp.2013.02.022
pubmed: 23562768
Coles CE et al (2017) Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. The Lancet 390:1048–1060. https://doi.org/10.1016/s0140-6736(17)31145-5
doi: 10.1016/s0140-6736(17)31145-5
Comito T et al (2017) Can stereotactic body radiation therapy be a viable and efficient therapeutic option for unresectable locally advanced pancreatic adenocarcinoma? Results of a Phase 2 Study. Technol Cancer Rese Treat 16:295–301. https://doi.org/10.1177/1533034616650778
doi: 10.1177/1533034616650778
Conway JL et al (2017) Secondary Breast Cancer Risk by Radiation Volume in Women With Hodgkin Lymphoma. Int J Radiat Oncol Biol Phys 97:35–41. https://doi.org/10.1016/j.ijrobp.2016.10.004
doi: 10.1016/j.ijrobp.2016.10.004
pubmed: 27979454
Correa C et al (2017) Accelerated Partial Breast Irradiation: executive summary for the update of an ASTRO Evidence-Based Consensus Statement. Pract Radiat Oncol 7:73–79. https://doi.org/10.1016/j.prro.2016.09.007
doi: 10.1016/j.prro.2016.09.007
pubmed: 27866865
Dan TD et al (2015) Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: updated results of an institutional clinical management approach. Oral Oncol 51:616–621. https://doi.org/10.1016/j.oraloncology.2015.03.013
doi: 10.1016/j.oraloncology.2015.03.013
pubmed: 25868716
Dawson LA, Anzai Y, Marsh L, Martel MK, Paulino A, Ship JA, Eisbruch A (2000) Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 46:1117–1126. https://doi.org/10.1016/s0360-3016(99)00550-7
doi: 10.1016/s0360-3016(99)00550-7
pubmed: 10725621
pmcid: 10725621
Depaus J, Delcourt A, Andre M (2019) Therapeutic recommendations for early stage Hodgkin lymphomas. Br J Haematol 184:9–16. https://doi.org/10.1111/bjh.15623
doi: 10.1111/bjh.15623
pubmed: 30485401
pmcid: 30485401
Due AK et al (2014) Recurrences after intensity modulated radiotherapy for head and neck squamous cell carcinoma more likely to originate from regions with high baseline [18F]-FDG uptake. Radiother Oncol 111:360–365. https://doi.org/10.1016/j.radonc.2014.06.001
doi: 10.1016/j.radonc.2014.06.001
pubmed: 24993331
pmcid: 24993331
Eggermont AMM, Robert C, Ribas A (2018) The new era of adjuvant therapies for melanoma. Nat Rev Clin Oncol 15:535–536. https://doi.org/10.1038/s41571-018-0048-5
doi: 10.1038/s41571-018-0048-5
pubmed: 29849093
pmcid: 29849093
Eichenauer DA et al (2018) Hodgkin lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 29:iV19–iv29. https://doi.org/10.1093/annonc/mdy080
doi: 10.1093/annonc/mdy080
pubmed: 32169225
pmcid: 32169225
Fokas E, O'Neill E, Gordon-Weeks A, Mukherjee S, McKenna WG, Muschel RJ (2015) Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic. Biochem Biophys Acta 1855:61–82. https://doi.org/10.1016/j.bbcan.2014.12.001
doi: 10.1016/j.bbcan.2014.12.001
pubmed: 25489989
pmcid: 25489989
Fuchs M et al (2019) Positron emission tomography-guided treatment in early-stage favorable Hodgkin Lymphoma: final results of the international, randomized phase III HD16 trial by the German Hodgkin Study Group. J Clin Oncol 37:2835–2845. https://doi.org/10.1200/JCO.19.00964
doi: 10.1200/JCO.19.00964
pubmed: 31498753
pmcid: 31498753
Giri S, Pathak R, Martin MG, Bhatt VR (2015) Incidence of breast cancer among female survivors of Hodgkin lymphoma: a US-population-based trend analysis from 1973 to 2011. Blood 126:1861–1863. https://doi.org/10.1182/blood-2015-05-647412
doi: 10.1182/blood-2015-05-647412
pubmed: 26282539
pmcid: 26282539
Girinsky T et al (2006) Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: concepts and guidelines. Radiother Oncol 79:270–277. https://doi.org/10.1016/j.radonc.2006.05.015
doi: 10.1016/j.radonc.2006.05.015
pubmed: 16797755
pmcid: 16797755
Girinsky T et al (2008) The conundrum of Hodgkin lymphoma nodes: to be or not to be included in the involved node radiation fields. The EORTC-GELA lymphoma group guidelines. Radiother Oncol 88:202–210. https://doi.org/10.1016/j.radonc.2008.05.012
doi: 10.1016/j.radonc.2008.05.012
pubmed: 18555548
pmcid: 18555548
Girinsky T et al (2014) Role of FDG-PET in the implementation of involved-node radiation therapy for Hodgkin lymphoma patients. Int J Radiat Oncol Biol Phys 89:1047–1052. https://doi.org/10.1016/j.ijrobp.2014.04.026
doi: 10.1016/j.ijrobp.2014.04.026
pubmed: 25035208
pmcid: 25035208
Goyal K et al (2012) Stereotactic body radiation therapy for nonresectable tumors of the pancreas. J Surg Res 174:319–325. https://doi.org/10.1016/j.jss.2011.07.044
doi: 10.1016/j.jss.2011.07.044
pubmed: 21937061
pmcid: 21937061
Gurka MK et al (2013) Stereotactic body radiation therapy with concurrent full-dose gemcitabine for locally advanced pancreatic cancer: a pilot trial demonstrating safety. Radiat Oncol 8:44. https://doi.org/10.1186/1748-717X-8-44
doi: 10.1186/1748-717X-8-44
pubmed: 23452509
pmcid: 23452509
Gurka MK et al (2017) Stereotactic body radiation therapy (SBRT) combined with chemotherapy for unresected pancreatic adenocarcinoma. Am J Clin Oncol 40:152–157. https://doi.org/10.1097/COC.0000000000000118
doi: 10.1097/COC.0000000000000118
pubmed: 25171298
pmcid: 25171298
Halasz LM et al (2016) Comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non-small cell lung cancer. Cancer 122:2091–2100. https://doi.org/10.1002/cncr.30009
doi: 10.1002/cncr.30009
pubmed: 27088755
pmcid: 27088755
Hammel P et al (2016) Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib: the LAP07 randomized clinical trial. JAMA J Am Med Assoc 315:1844–1853. https://doi.org/10.1001/jama.2016.4324
doi: 10.1001/jama.2016.4324
Hanna TP, Shafiq J, Delaney GP, Vinod SK, Thompson SR, Barton MB (2018) The population benefit of evidence-based radiotherapy: 5-Year local control and overall survival benefits. Radiother Oncol 126:191–197. https://doi.org/10.1016/j.radonc.2017.11.004
doi: 10.1016/j.radonc.2017.11.004
pubmed: 29229506
pmcid: 29229506
Haviland JS et al (2013) The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol 14:1086–1094. https://doi.org/10.1016/S1470-2045(13)70386-3
doi: 10.1016/S1470-2045(13)70386-3
pubmed: 24055415
pmcid: 24055415
Herman JM et al (2015) Phase 2 multi-institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma. Cancer 121:1128–1137. https://doi.org/10.1002/cncr.29161
doi: 10.1002/cncr.29161
pubmed: 25538019
pmcid: 25538019
Ho KF, Farnell DJ, Routledge JA, Burns MP, Sykes AJ, Slevin NJ, Davidson SE (2010) Comparison of patient-reported late treatment toxicity (LENT-SOMA) with quality of life (EORTC QLQ-C30 and QLQ-H&N35) assessment after head and neck radiotherapy. Radiother Oncol 97:270–275. https://doi.org/10.1016/j.radonc.2010.01.017
doi: 10.1016/j.radonc.2010.01.017
pubmed: 20554338
pmcid: 20554338
Hoyer M et al (2005) Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma. Radiother Oncol 76:48–53. https://doi.org/10.1016/j.radonc.2004.12.022
doi: 10.1016/j.radonc.2004.12.022
pubmed: 15990186
pmcid: 15990186
Jackson SM, Hay JH, Flores AD, Weir L, Wong FL, Schwindt C, Baerg B (1999) Cancer of the tonsil: the results of ipsilateral radiation treatment. Radiother Oncol 51:123–128. https://doi.org/10.1016/s0167-8140(99)00051-1
doi: 10.1016/s0167-8140(99)00051-1
pubmed: 10435802
pmcid: 10435802
Jensen K, Overgaard M, Grau C (2007) Morbidity after ipsilateral radiotherapy for oropharyngeal cancer. Radiother Oncol 85:90–97. https://doi.org/10.1016/j.radonc.2007.06.005
doi: 10.1016/j.radonc.2007.06.005
pubmed: 17604141
pmcid: 17604141
Kagei K et al (2000) Ipsilateral irradiation for carcinomas of tonsillar region and soft palate based on computed tomographic simulation. Radiother Oncol 54:117–121. https://doi.org/10.1016/s0167-8140(99)00179-6
doi: 10.1016/s0167-8140(99)00179-6
pubmed: 10699473
pmcid: 10699473
Kennedy WR et al (2016) Ipsilateral radiotherapy for squamous cell carcinoma of the tonsil. Eur Arch Otorhinolaryngol 273:2151–2156. https://doi.org/10.1007/s00405-015-3725-3
doi: 10.1007/s00405-015-3725-3
pubmed: 26223350
pmcid: 26223350
Kocher M et al. (2014) Stereotactic radiosurgery for treatment of brain metastases. A report of the DEGRO Working Group on Stereotactic Radiotherapy Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al] 190:521–532 doi:10.1007/s00066–014–0648–7
Kocher M et al (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952–26001 study. J Clin Oncol 29:134–141. https://doi.org/10.1200/JCO.2010.30.1655
doi: 10.1200/JCO.2010.30.1655
pubmed: 21041710
pmcid: 21041710
Koo TR, Wu HG (2013) Long-term results of ipsilateral radiotherapy for tonsil cancer. Radiat Oncol J 31:66–71. https://doi.org/10.3857/roj.2013.31.2.66
doi: 10.3857/roj.2013.31.2.66
pubmed: 23865002
pmcid: 23865002
Koong AC et al (2004) Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 58:1017–1021. https://doi.org/10.1016/j.ijrobp.2003.11.004
doi: 10.1016/j.ijrobp.2003.11.004
pubmed: 15001240
pmcid: 15001240
Krishnan S et al (2016) Focal radiation therapy dose escalation improves overall survival in locally advanced pancreatic cancer patients receiving induction chemotherapy and consolidative chemoradiation. Int J Radiat Oncol Biol Phys 94:755–765. https://doi.org/10.1016/j.ijrobp.2015.12.003
doi: 10.1016/j.ijrobp.2015.12.003
pubmed: 26972648
pmcid: 26972648
Lacas B et al (2017) Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis. Lancet Oncol 18:1221–1237. https://doi.org/10.1016/S1470-2045(17)30458-8
doi: 10.1016/S1470-2045(17)30458-8
pubmed: 28757375
pmcid: 28757375
Levy A et al (2018) Diversity of brain metastases screening and management in non-small cell lung cancer in Europe: results of the European Organisation for Research and Treatment of Cancer Lung Cancer Group survey. Eur J Cancer 93:37–46. https://doi.org/10.1016/j.ejca.2018.01.067
doi: 10.1016/j.ejca.2018.01.067
pubmed: 29477100
pmcid: 29477100
Li D, Xie K, Wolff R, Abbruzzese JL (2004) Pancreatic cancer. Lancet 363:1049–1057. https://doi.org/10.1016/S0140-6736(04)15841-8
doi: 10.1016/S0140-6736(04)15841-8
pubmed: 15051286
pmcid: 15051286
Lin X, DeAngelis LM (2015) Treatment of brain metastases. J Clin Oncol 33:3475–3484. https://doi.org/10.1200/JCO.2015.60.9503
doi: 10.1200/JCO.2015.60.9503
pubmed: 26282648
pmcid: 26282648
Lin JC, Jen YM, Li MH, Chao HL, Tsai JT (2015) Comparing outcomes of stereotactic body radiotherapy with intensity-modulated radiotherapy for patients with locally advanced unresectable pancreatic cancer. Eur J Gastroenterol Hepatol 27:259–264. https://doi.org/10.1097/MEG.0000000000000283
doi: 10.1097/MEG.0000000000000283
pubmed: 25629569
pmcid: 25629569
Liu C, Dutu G, Peters LJ, Rischin D, Corry J (2014) Tonsillar cancer: the Peter MacCallum experience with unilateral and bilateral irradiation. Head Neck 36:317–322. https://doi.org/10.1002/hed.23297
doi: 10.1002/hed.23297
pubmed: 23729387
pmcid: 23729387
Livi L et al (2015) Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. Eur J Cancer 51:451–463. https://doi.org/10.1016/j.ejca.2014.12.013
doi: 10.1016/j.ejca.2014.12.013
pubmed: 25605582
pmcid: 25605582
Lynch J, Lal P, Schick U, Nutting CM, Newbold K, Harrington K, Bhide S (2014) Multiple cervical lymph node involvement and extra-capsular extension predict for contralateral nodal recurrence after ipsilateral radiotherapy for squamous cell carcinoma of the tonsil. Oral Oncol 50:901–906. https://doi.org/10.1016/j.oraloncology.2014.06.019
doi: 10.1016/j.oraloncology.2014.06.019
pubmed: 25052236
pmcid: 25052236
Machtay M et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26:3582–3589. https://doi.org/10.1200/JCO.2007.14.8841
doi: 10.1200/JCO.2007.14.8841
pubmed: 18559875
pmcid: 18559875
Mahadevan A et al (2011) Induction gemcitabine and stereotactic body radiotherapy for locally advanced nonmetastatic pancreas cancer. Int J Radiat Oncol Biol Phys 81:e615–622. https://doi.org/10.1016/j.ijrobp.2011.04.045
doi: 10.1016/j.ijrobp.2011.04.045
pubmed: 21658854
pmcid: 21658854
Maraldo MV, Aznar MC, Vogelius IR, Petersen PM, Specht L (2013) Involved node radiation therapy: an effective alternative in early-stage hodgkin lymphoma. Int J Radiat Oncol Biol Phys 85:1057–1065. https://doi.org/10.1016/j.ijrobp.2012.08.041
doi: 10.1016/j.ijrobp.2012.08.041
pubmed: 23200817
pmcid: 23200817
Mazzola R et al (2018) Linac-based stereotactic body radiation therapy for unresectable locally advanced pancreatic cancer: risk-adapted dose prescription and image-guided delivery. Strahlenther Onkol 194:835–842
doi: 10.1007/s00066-018-1306-2
pubmed: 29696321
pmcid: 29696321
Meduri B, Baldissera A, Galeandro M, Donini E (2017) Accelerated PBI vs standard radiotherapy (IRMA-trial): interim cosmetic and toxicity results. Radiother Oncol 123:S303
doi: 10.1016/S0167-8140(17)31008-3
Mehta MP et al (2005) The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys 63:37–46. https://doi.org/10.1016/j.ijrobp.2005.05.023
doi: 10.1016/j.ijrobp.2005.05.023
pubmed: 16111570
pmcid: 16111570
Mellon EA et al (2015) Long-term outcomes of induction chemotherapy and neoadjuvant stereotactic body radiotherapy for borderline resectable and locally advanced pancreatic adenocarcinoma. Acta Oncol 54(7):979–985
doi: 10.3109/0284186X.2015.1004367
pubmed: 25734581
pmcid: 25734581
Mendenhall WM, Million RR, Cassisi NJ (1980) Elective neck irradiation in squamous-cell carcinoma of the head and neck. Head Neck Surg 3:15–20. https://doi.org/10.1002/hed.2890030105
doi: 10.1002/hed.2890030105
pubmed: 7410098
pmcid: 7410098
Nam TK et al (2005) Gamma knife surgery for brain metastases in patients harboring four or more lesions: survival and prognostic factors. J Neurosurg 102(Suppl):147–150. https://doi.org/10.3171/jns.2005.102.s_supplement.0147
doi: 10.3171/jns.2005.102.s_supplement.0147
pubmed: 15662799
pmcid: 15662799
Olivotto IA et al (2013) Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. J Clin Oncol 31:4038–4045. https://doi.org/10.1200/JCO.2013.50.5511
doi: 10.1200/JCO.2013.50.5511
pubmed: 23835717
pmcid: 23835717
O'Sullivan B et al (2001) The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys 51:332–343. https://doi.org/10.1016/s0360-3016(01)01613-3
doi: 10.1016/s0360-3016(01)01613-3
pubmed: 11567806
pmcid: 11567806
Passoni P et al (2013) Hypofractionated image-guided IMRT in advanced pancreatic cancer with simultaneous integrated boost to infiltrated vessels concomitant with capecitabine: a phase I study. Int J Radiat Oncol Biol Phys 87:1000–1006. https://doi.org/10.1016/j.ijrobp.2013.09.012
doi: 10.1016/j.ijrobp.2013.09.012
pubmed: 24267968
pmcid: 24267968
Patchell RA (2003) The management of brain metastases. Cancer Treat Rev 29:533–540. https://doi.org/10.1016/s0305-7372(03)00105-1
doi: 10.1016/s0305-7372(03)00105-1
pubmed: 14585263
Patchell RA et al (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322:494–500. https://doi.org/10.1056/NEJM199002223220802
doi: 10.1056/NEJM199002223220802
pubmed: 2405271
Paumier A et al (2012) Dosimetric benefits of intensity-modulated radiotherapy combined with the deep-inspiration breath-hold technique in patients with mediastinal Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys 82:1522–1527. https://doi.org/10.1016/j.ijrobp.2011.05.015
doi: 10.1016/j.ijrobp.2011.05.015
pubmed: 21705151
Peterson D et al (2015) Predictors of adverse cosmetic outcome in the RAPID trial: an exploratory analysis. Int J Radiat Oncol Biol Phys 91:968–976. https://doi.org/10.1016/j.ijrobp.2014.12.040
doi: 10.1016/j.ijrobp.2014.12.040
pubmed: 25832689
Pignon JP, le Maitre A, Maillard E, Bourhis J, Group M-NC (2009) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 92:4–14. https://doi.org/10.1016/j.radonc.2009.04.014
doi: 10.1016/j.radonc.2009.04.014
Pollom EL et al (2014) Single- versus multifraction stereotactic body radiation therapy for pancreatic adenocarcinoma: outcomes and toxicity. Int J Radiat Oncol Biol Phys 90:918–925. https://doi.org/10.1016/j.ijrobp.2014.06.066
doi: 10.1016/j.ijrobp.2014.06.066
pubmed: 25585785
pmcid: 25585785
Polistina F et al (2010) Unresectable locally advanced pancreatic cancer: a multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration. Ann Surg Oncol 17(8):2092–2101
doi: 10.1245/s10434-010-1019-y
pubmed: 20224860
pmcid: 20224860
Rackley TP, Namelo WC, Palaniappan N, Cole N, Owens DM, Evans M (2017) Unilateral radiotherapy for surgically resected lateralized squamous cell carcinoma of the tonsil. Head Neck 39:17–23. https://doi.org/10.1002/hed.24541
doi: 10.1002/hed.24541
pubmed: 27438333
pmcid: 27438333
Raktoe SA, Dehnad H, Raaijmakers CP, Braunius W, Terhaard CH (2013) Origin of tumor recurrence after intensity modulated radiation therapy for oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 85:136–141. https://doi.org/10.1016/j.ijrobp.2012.02.042
doi: 10.1016/j.ijrobp.2012.02.042
pubmed: 22541959
pmcid: 22541959
Robin TP et al (2018) Excellent outcomes with radiosurgery for multiple brain metastases in ALK and EGFR driven non-small cell lung cancer. J Thorac Oncol 13:715–720. https://doi.org/10.1016/j.jtho.2017.12.006
doi: 10.1016/j.jtho.2017.12.006
pubmed: 29269007
pmcid: 29269007
Roh JL et al (2014) 18F fluorodeoxyglucose PET/CT in head and neck squamous cell carcinoma with negative neck palpation findings: a prospective study. Radiology 271:153–161. https://doi.org/10.1148/radiol.13131470
doi: 10.1148/radiol.13131470
pubmed: 24475791
Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A (2009) Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. Int J Radiat Oncol Biol Phys 74:1365–1370. https://doi.org/10.1016/j.ijrobp.2008.10.023
doi: 10.1016/j.ijrobp.2008.10.023
pubmed: 19168295
Rutten H et al (2011) Long-term outcome and morbidity after treatment with accelerated radiotherapy and weekly cisplatin for locally advanced head-and-neck cancer: results of a multidisciplinary late morbidity clinic. Int J Radiat Oncol Biol Phys 81:923–929. https://doi.org/10.1016/j.ijrobp.2010.07.013
doi: 10.1016/j.ijrobp.2010.07.013
pubmed: 21095074
Rwigema JC et al (2011) Stereotactic body radiotherapy in the treatment of advanced adenocarcinoma of the pancreas. Am J Clin Oncol 34:63–69
doi: 10.1097/COC.0b013e3181d270b4
pubmed: 20308870
Sahgal A, Ruschin M, Ma L, Verbakel W, Larson D, Brown PD (2017) Stereotactic radiosurgery alone for multiple brain metastases? A review of clinical and technical issues. Neuro-Oncology 19:2–15. https://doi.org/10.1093/neuonc/nox001
doi: 10.1093/neuonc/nox001
Salvetti DJ, Nagaraja TG, McNeill IT, Xu Z, Sheehan J (2013) Gamma Knife surgery for the treatment of 5 to 15 metastases to the brain: clinical article. J Neurosurg 118:1250–1257. https://doi.org/10.3171/2013.2.JNS121213
doi: 10.3171/2013.2.JNS121213
pubmed: 23540265
Schaapveld M et al (2015) Second cancer risk up to 40 years after treatment for Hodgkin's Lymphoma. N Engl J Med 373:2499–2511. https://doi.org/10.1056/NEJMoa1505949
doi: 10.1056/NEJMoa1505949
pubmed: 26699166
Schellenberg D et al (2008) Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 72:678–686. https://doi.org/10.1016/j.ijrobp.2008.01.051
doi: 10.1016/j.ijrobp.2008.01.051
pubmed: 18395362
Schwartz DL et al (2017) SBRT for early-stage glottic larynx cancer-Initial clinical outcomes from a phase I clinical trial. PLoS ONE 12:e0172055. https://doi.org/10.1371/journal.pone.0172055
doi: 10.1371/journal.pone.0172055
pubmed: 28253270
pmcid: 5333979
Seiwert TY et al (2019) OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer. Ann Oncol 30:297–302. https://doi.org/10.1093/annonc/mdy522
doi: 10.1093/annonc/mdy522
pubmed: 30481287
Shoushtari AN et al (2010) Clinical nodal staging of T1–2 tonsillar squamous cell carcinoma stratified by p16 status and implications for ipsilateral neck irradiation. Cancer J 16:284–287. https://doi.org/10.1097/PPO.0b013e3181ddd088
doi: 10.1097/PPO.0b013e3181ddd088
pubmed: 20526108
Silverstein MJ et al (2018) Intraoperative radiation therapy (IORT): a series of 1000 tumors. Ann Surg Oncol 25:2987–2993. https://doi.org/10.1245/s10434-018-6614-3
doi: 10.1245/s10434-018-6614-3
pubmed: 29968030
Sinha P, Pipkorn P, Thorstad WL, Gay HA, Haughey BH (2016) Does elimination of planned postoperative radiation to the primary bed in p16-positive, transorally-resected oropharyngeal carcinoma associate with poorer outcomes? Oral Oncol 61:127–134. https://doi.org/10.1016/j.oraloncology.2016.08.013
doi: 10.1016/j.oraloncology.2016.08.013
pubmed: 27688115
Smith BD et al (2018) Radiation therapy for the whole breast: executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Pract Radiat Oncol 8:145–152. https://doi.org/10.1016/j.prro.2018.01.012
doi: 10.1016/j.prro.2018.01.012
pubmed: 29545124
Soffietti R et al (2013) A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life results. J Clin Oncol 31:65–72. https://doi.org/10.1200/JCO.2011.41.0639
doi: 10.1200/JCO.2011.41.0639
pubmed: 23213105
Soffietti R et al (2017) Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO). Neuro-oncology 19:162–174. https://doi.org/10.1093/neuonc/now241
doi: 10.1093/neuonc/now241
pubmed: 28391295
pmcid: 5620494
Specht L et al (2014) Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the international lymphoma radiation oncology group (ILROG). Int J Radiat Oncol Biol Phys 89:854–862. https://doi.org/10.1016/j.ijrobp.2013.05.005
doi: 10.1016/j.ijrobp.2013.05.005
pubmed: 23790512
Sperduto PW et al (2014) Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1–3 brain metastases; poststratified by the graded prognostic assessment (GPA). Int J Radiat Oncol Biol Phys 90:526–531. https://doi.org/10.1016/j.ijrobp.2014.07.002
doi: 10.1016/j.ijrobp.2014.07.002
pubmed: 25304947
pmcid: 4700538
Stauder MC, Miller RC (2010) stereotactic body radiation therapy (SBRT) for unresectable pancreatic carcinoma. Cancers 2:1565–1575. https://doi.org/10.3390/cancers2031565
doi: 10.3390/cancers2031565
pubmed: 24281173
pmcid: 3837322
Strnad V et al (2016) 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial. The Lancet 387:229–238. https://doi.org/10.1016/s0140-6736(15)00471-7
doi: 10.1016/s0140-6736(15)00471-7
Studer G, Luetolf UM, Glanzmann C (2007) Locoregional failure analysis in head-and-neck cancer patients treated with IMRT Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al] 183:417–423. doi:10.1007/s00066–007–1663–8 (discussion 424–415)
Vaidya JS et al (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 376:91–102. https://doi.org/10.1016/S0140-6736(10)60837-9
doi: 10.1016/S0140-6736(10)60837-9
pubmed: 20570343
pmcid: 20570343
Vaidya JS et al (2014) Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT—a randomised trial. Lancet 383:603–613. https://doi.org/10.1016/S0140-6736(13)61950-9
doi: 10.1016/S0140-6736(13)61950-9
pubmed: 24224997
pmcid: 24224997
van den Bosch S, Vogel WV, Raaijmakers CP, Dijkema T, Terhaard CHJ, Al-Mamgani A, Kaanders J (2018) Implications of improved diagnostic imaging of small nodal metastases in head and neck cancer: Radiotherapy target volume transformation and dose de-escalation. Radiother Oncol 128:472–478. https://doi.org/10.1016/j.radonc.2018.04.020
doi: 10.1016/j.radonc.2018.04.020
pubmed: 29731161
pmcid: 29731161
Varadhachary GR et al (2006) Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy. Ann Surg Oncol 13:1035–1046. https://doi.org/10.1245/ASO.2006.08.011
doi: 10.1245/ASO.2006.08.011
pubmed: 16865597
pmcid: 16865597
Vergeer MR et al (2010) Ipsilateral irradiation for oral and oropharyngeal carcinoma treated with primary surgery and postoperative radiotherapy. Int J Radiat Oncol Biol Phys 78:682–688. https://doi.org/10.1016/j.ijrobp.2009.08.042
doi: 10.1016/j.ijrobp.2009.08.042
pubmed: 20188492
pmcid: 20188492
Veronesi U et al (2013) Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 14:1269–1277. https://doi.org/10.1016/S1470-2045(13)70497-2
doi: 10.1016/S1470-2045(13)70497-2
pubmed: 24225155
pmcid: 24225155
Villaflor VM et al (2016) Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer. Ann Oncol 27:908–913. https://doi.org/10.1093/annonc/mdw051
doi: 10.1093/annonc/mdw051
pubmed: 26884588
pmcid: 26884588
Weber DC, Peguret N, Dipasquale G, Cozzi L (2009) Involved-node and involved-field volumetric modulated arc vs. fixed beam intensity-modulated radiotherapy for female patients with early-stage supra-diaphragmatic Hodgkin lymphoma: a comparative planning study. Int J Radiat Oncol Biol Phys 75:1578–1586. https://doi.org/10.1016/j.ijrobp.2009.05.012
doi: 10.1016/j.ijrobp.2009.05.012
pubmed: 19596171
pmcid: 19596171
Weber DC, Johanson S, Peguret N, Cozzi L, Olsen DR (2011) Predicted risk of radiation-induced cancers after involved field and involved node radiotherapy with or without intensity modulation for early-stage hodgkin lymphoma in female patients. Int J Radiat Oncol Biol Phys 81:490–497. https://doi.org/10.1016/j.ijrobp.2010.05.035
doi: 10.1016/j.ijrobp.2010.05.035
pubmed: 20800383
pmcid: 20800383
Whelan TJ et al (2010) Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 362:513–520. https://doi.org/10.1056/NEJMoa0906260
doi: 10.1056/NEJMoa0906260
pubmed: 20147717
Witkowska M, Majchrzak A, Smolewski P (2015) The role of radiotherapy in Hodgkin's lymphoma: what has been achieved during the last 50 years? Biomed Res Int 2015:485071. https://doi.org/10.1155/2015/485071
doi: 10.1155/2015/485071
pubmed: 25705661
pmcid: 4331316
Worni M et al (2013) Modest improvement in overall survival for patients with metastatic pancreatic cancer: a trend analysis using the surveillance, epidemiology, and end results registry from 1988 to 2008. Pancreas 42:1157–1163. https://doi.org/10.1097/MPA.0b013e318291fbc5
doi: 10.1097/MPA.0b013e318291fbc5
pubmed: 23867367
pmcid: 23867367
Yamamoto M, Kawabe T, Sato Y, Higuchi Y, Nariai T, Watanabe S, Kasuya H (2014) Stereotactic radiosurgery for patients with multiple brain metastases: a case-matched study comparing treatment results for patients with 2–9 versus 10 or more tumors. J Neurosurg 121(Suppl):16–25. https://doi.org/10.3171/2014.8.GKS141421
doi: 10.3171/2014.8.GKS141421
pubmed: 25434933
Yamamoto M et al (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol 15:387–395. https://doi.org/10.1016/S1470-2045(14)70061-0
doi: 10.1016/S1470-2045(14)70061-0
pubmed: 24621620
pmcid: 24621620
Yamazaki Y et al (2008) Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer. Ann Nucl Med 22:177–184. https://doi.org/10.1007/s12149-007-0097-9
doi: 10.1007/s12149-007-0097-9
pubmed: 18498032
pmcid: 18498032
Zhang W (2015) Radiotherapy in early stage classical Hodgkin lymphoma: past, present and future. Chin Clin Oncol 4:6. https://doi.org/10.3978/j.issn.2304-3865.2015.03.05
doi: 10.3978/j.issn.2304-3865.2015.03.05
pubmed: 25841713
pmcid: 25841713