Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children.

Adult Autism Spectrum Disorder / epidemiology Canada / epidemiology Child Child, Preschool Environmental Pollutants / metabolism Female Folic Acid / metabolism Humans Male Maternal Exposure / statistics & numerical data Phthalic Acids / metabolism Pregnancy Prenatal Exposure Delayed Effects / epidemiology

Journal

Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411

Informations de publication

Date de publication:
02 2020
Historique:
entrez: 20 2 2020
pubmed: 20 2 2020
medline: 22 7 2020
Statut: ppublish

Résumé

The etiology of autism spectrum disorder is poorly understood. Few studies have investigated the link between endocrine-disrupting chemicals and autistic traits. We examined the relationship between gestational phthalates and autistic traits in 3- to 4-y-old Canadian children. We also investigated potential effect modification by sex and folic acid supplementation. We enrolled 2,001 Mean total SRS Higher gestational concentrations of some phthalate metabolites were associated with higher scores of autistic traits as measured by the SRS-2 in boys, but not girls; these small size effects were mitigated by first trimester-of-pregnancy folic acid supplementation. https://doi.org/10.1289/EHP5621.

Sections du résumé

BACKGROUND
The etiology of autism spectrum disorder is poorly understood. Few studies have investigated the link between endocrine-disrupting chemicals and autistic traits. We examined the relationship between gestational phthalates and autistic traits in 3- to 4-y-old Canadian children. We also investigated potential effect modification by sex and folic acid supplementation.
METHODS
We enrolled 2,001
RESULTS
Mean total SRS
CONCLUSIONS
Higher gestational concentrations of some phthalate metabolites were associated with higher scores of autistic traits as measured by the SRS-2 in boys, but not girls; these small size effects were mitigated by first trimester-of-pregnancy folic acid supplementation. https://doi.org/10.1289/EHP5621.

Identifiants

DOI: 10.1289/EHP5621 PMID: 32073305 PMC: PMC7064316
pubmed: 32073305
doi: 10.1289/EHP5621
pmc: PMC7064316
doi:

Substances chimiques

Environmental Pollutants 0
Phthalic Acids 0
phthalic acid 6O7F7IX66E
Folic Acid 935E97BOY8

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

27004

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES024381
Pays : United States
Organisme : CIHR
ID : MOP-81285
Pays : Canada
Organisme : CIHR
ID : MFE-140907
Pays : Canada
Organisme : CIHR
ID : MFE-339339-152889
Pays : Canada

Commentaires et corrections

Type : CommentIn

Références

Environ Int. 2019 Jan;122:222-230
pubmed: 30477814
Int J Mol Sci. 2012;13(8):10143-53
pubmed: 22949852
Neurotoxicology. 2009 Jul;30(4):522-8
pubmed: 19375452
Neurotoxicol Teratol. 2013 Jul-Aug;38:1-5
pubmed: 23591055
Int J Epidemiol. 2014 Apr;43(2):443-64
pubmed: 24518932
Environ Health Perspect. 2017 Sep 08;125(9):097007
pubmed: 28934093
Autism Res. 2008 Dec;1(6):354-63
pubmed: 19360690
Mol Autism. 2017 Oct 2;8:51
pubmed: 29026508
Occup Environ Med. 2007 Aug;64(8):562-8
pubmed: 17053019
Environ Res. 2018 Apr;162:261-270
pubmed: 29367177
Paediatr Perinat Epidemiol. 2013 Jul;27(4):415-25
pubmed: 23772943
J Aging Health. 1993 May;5(2):179-93
pubmed: 10125443
Environ Mol Mutagen. 2017 Jul;58(6):398-410
pubmed: 28556291
Epidemiology. 2004 Sep;15(5):615-25
pubmed: 15308962
FASEB J. 2006 Jan;20(1):43-9
pubmed: 16394266
J Autism Dev Disord. 2003 Aug;33(4):427-33
pubmed: 12959421
Environ Health. 2015 Jun 26;14:56
pubmed: 26108271
Environ Int. 2014 Jul;68:55-65
pubmed: 24709781
Environ Int. 2014 Jan;62:1-11
pubmed: 24161445
Am J Clin Nutr. 2018 Jun 1;107(6):1027-1034
pubmed: 29767673
Environ Int. 2018 Dec;121(Pt 1):764-793
pubmed: 30336412
Pediatrics. 2013 Nov;132(5):e1284-94
pubmed: 24101766
BMJ. 2003 Jan 25;326(7382):219
pubmed: 12543843
Environ Health Perspect. 2011 Oct;119(10):1495-500
pubmed: 21737372
J Autism Dev Disord. 2012 Nov;42(11):2450-9
pubmed: 22407579
Hum Reprod. 2015 Apr;30(4):963-72
pubmed: 25697839
Arch Gen Psychiatry. 2011 Nov;68(11):1095-102
pubmed: 21727249
Environ Health Perspect. 2017 Jun 16;125(6):067008
pubmed: 28657891
Neurotoxicology. 2019 Jul;73:199-212
pubmed: 31004626
Toxicol Sci. 2008 Sep;105(1):153-65
pubmed: 18411233
Reprod Biol Endocrinol. 2015 Jan 17;13:4
pubmed: 25596636
Acta Paediatr. 2019 Apr;108(4):600-610
pubmed: 30466185
Environ Res. 2015 Oct;142:51-60
pubmed: 26101203
Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):218-27
pubmed: 18226077
Toxicol Appl Pharmacol. 1992 Jul;115(1):116-23
pubmed: 1321518
Neurotoxicology. 2007 Mar;28(2):245-51
pubmed: 16806481
Adv Nutr. 2012 Jan;3(1):21-38
pubmed: 22332098
Environ Health Perspect. 2019 Apr;127(4):46001
pubmed: 30942615
Br J Nutr. 2015 Sep 14;114(5):663-72
pubmed: 26243379
Environ Health. 2018 Dec 5;17(1):85
pubmed: 30518373
Environ Int. 2011 Jul;37(5):858-66
pubmed: 21440302
Neurotoxicology. 2011 Mar;32(2):261-7
pubmed: 21182865
Br J Psychiatry. 2009 Jul;195(1):7-14
pubmed: 19567888
J Expo Sci Environ Epidemiol. 2015 May;25(3):231-9
pubmed: 25248937
Environ Health Perspect. 2010 Jul;118(7):1039-46
pubmed: 20308033
Epidemiol Prev. 2014 Sep-Oct;38(5):335-41
pubmed: 25387748
JAMA Psychiatry. 2013 Jan;70(1):71-7
pubmed: 23404082
Autism Res. 2018 Jan;11(1):69-80
pubmed: 29120534
JAMA. 2017 Sep 26;318(12):1182-1184
pubmed: 28973605
MMWR Surveill Summ. 2018 Apr 27;67(6):1-23
pubmed: 29701730
Curr Opin Pediatr. 2010 Apr;22(2):219-25
pubmed: 20087185
Hum Reprod. 2007 Oct;22(10):2715-22
pubmed: 17704099
Neurotoxicology. 2016 Jul;55:92-101
pubmed: 27208563
Appl Physiol Nutr Metab. 2012 Apr;37(2):284-92
pubmed: 22452580
JAMA Psychiatry. 2014 Aug;71(8):936-42
pubmed: 25100167
Neurotoxicology. 2009 Sep;30(5):822-31
pubmed: 19822263
Arch Gen Psychiatry. 2003 May;60(5):524-30
pubmed: 12742874
Environ Health Perspect. 2014 Mar;122(3):235-41
pubmed: 24425099
Eur J Endocrinol. 2004 Nov;151 Suppl 3:U25-37
pubmed: 15554884
Environ Health Perspect. 2012 May;120(5):739-45
pubmed: 22262702
Environ Health Perspect. 2014 May;122(5):513-20
pubmed: 24622245
BMJ. 2019 Mar 20;364:l962
pubmed: 30894343
Carcinogenesis. 1993 Apr;14(4):551-7
pubmed: 8472313
J Autism Dev Disord. 2011 Jan;41(1):66-72
pubmed: 20422277
Am J Clin Nutr. 2017 May;105(5):1101-1109
pubmed: 28298392
BMC Med. 2013 Jun 24;11:152
pubmed: 23800242
PLoS One. 2016 Jul 25;11(7):e0159398
pubmed: 27455052
Altern Med Rev. 2008 Sep;13(3):216-26
pubmed: 18950248
Environ Health Perspect. 2013 Mar;121(3):380-6
pubmed: 23249813
Eur Child Adolesc Psychiatry. 2014 Feb;23(2):81-93
pubmed: 23719758

Auteurs

Youssef Oulhote (Y)

Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, Amherst, Massachusetts, USA.
Centre Hospitalier Universitaire (CHU) de Québec Research Centre and School of Psychology, Laval University, Quebec, Quebec, Canada.

Bruce Lanphear (B)

Child and Family Research Institute, BC Children's Hospital Research Institute and Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.

Joseph M Braun (JM)

Department of Epidemiology, Brown University, Providence, Rhode Island, USA.

Glenys M Webster (GM)

Child and Family Research Institute, BC Children's Hospital Research Institute and Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.

Tye E Arbuckle (TE)

Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

Taylor Etzel (T)

Department of Epidemiology, Brown University, Providence, Rhode Island, USA.

Nadine Forget-Dubois (N)

Centre Hospitalier Universitaire (CHU) de Québec Research Centre and School of Psychology, Laval University, Quebec, Quebec, Canada.

Jean R Seguin (JR)

CHU Sainte-Justine Research Centre and Department of Psychiatry, School of Medicine, Université de Montréal, Montreal, Quebec, Canada.

Maryse F Bouchard (MF)

CHU Sainte-Justine Research Centre and Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, Canada.

Amanda MacFarlane (A)

Nutrition Research Division, Health Canada, Ottawa, Ontario, Canada.

Emmanuel Ouellet (E)

Centre Hospitalier Universitaire (CHU) de Québec Research Centre and School of Psychology, Laval University, Quebec, Quebec, Canada.

William Fraser (W)

Centre de Sherbrooke Research Centre, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Gina Muckle (G)

Centre Hospitalier Universitaire (CHU) de Québec Research Centre and School of Psychology, Laval University, Quebec, Quebec, Canada.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › Canada › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Acide folique › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition maternelle › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acides phtaliques › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Gestational Exposures to Phthalates and Folic...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Gestational Exposures to Phthalates and Folic...