Multiomics Substrates of Resistance to Emerging Pathogens? Transcriptome and Proteome Profile of a Vancomycin-Resistant

Anti-Bacterial Agents / pharmacology Bacterial Proteins / genetics Computational Biology / methods Drug Resistance, Microbial Enterococcus faecalis / classification Genome, Bacterial Genotype Gram-Positive Bacterial Infections / drug therapy Humans Microbial Sensitivity Tests Molecular Sequence Annotation Phylogeny Proteome Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stress, Physiological Transcriptome Vancomycin / pharmacology Vancomycin-Resistant Enterococci / classification
Enterococcus antibiotic resistance biomarkers multiomics proteomics transcriptomics translational research

Journal

Omics : a journal of integrative biology
ISSN: 1557-8100
Titre abrégé: OMICS
Pays: United States
ID NLM: 101131135

Informations de publication

Date de publication:
02 2020
Historique:
entrez: 20 2 2020
pubmed: 20 2 2020
medline: 21 10 2020
Statut: ppublish

Résumé

Antibiotic resistance and hospital acquired infections are on the rise worldwide. Vancomycin-resistant enterococci have been reported in clinical settings in recent decades. In this multiomics study, we provide comprehensive proteomic and transcriptomic analyses of a vancomycin-resistant

Identifiants

DOI: 10.1089/omi.2019.0164 PMID: 32073998
pubmed: 32073998
doi: 10.1089/omi.2019.0164
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Proteome 0
Vancomycin 6Q205EH1VU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

81-95

Auteurs

Luís Pinto (L)

Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Functional Genomics and Proteomics Unit, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Veterinary Science Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.

Carmen Torres (C)

Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain.

Concha Gil (C)

Departamento de Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.

Hugo M Santos (HM)

LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal.

José Luís Capelo (JL)

LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal.

Vítor Borges (V)

Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal.

João Paulo Gomes (JP)

Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal.

Catarina Silva (C)

Innovation and Technology Unit, Department of Human Genetics, National Institute of Health, Lisbon, Portugal.

Luís Vieira (L)

Innovation and Technology Unit, Department of Human Genetics, National Institute of Health, Lisbon, Portugal.

Patrícia Poeta (P)

Veterinary Science Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal.

Gilberto Igrejas (G)

Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Functional Genomics and Proteomics Unit, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Enterococcaceae › Enterococcus › Enterococcus faecalis › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Annotation de séquence moléculaire › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse MALDI › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Glycopeptides › Vancomycine › Multiomics Substrates of Resistance to...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Lactobacillales › Enterococcaceae › Enterococcus › Entérocoques résistants à la vancomycine › Multiomics Substrates of Resistance to...