Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes.
gestational diabetes
glycated albumin
methylglyoxal
platelet-activating factor
tumor necrosis factor α
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Feb 2020
14 Feb 2020
Historique:
received:
31
12
2019
revised:
09
02
2020
accepted:
11
02
2020
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
18
12
2020
Statut:
epublish
Résumé
In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM. We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism. In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4-47.5) ng/mL to 40.1 (30.5-80.5) ng/mL ( These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results.
Sections du résumé
BACKGROUND
BACKGROUND
In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM.
METHODS
METHODS
We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism.
RESULTS
RESULTS
In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4-47.5) ng/mL to 40.1 (30.5-80.5) ng/mL (
CONCLUSION
CONCLUSIONS
These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results.
Identifiants
pubmed: 32074941
pii: nu12020479
doi: 10.3390/nu12020479
pmc: PMC7071306
pii:
doi:
Substances chimiques
Biomarkers
0
Glycation End Products, Advanced
0
Platelet Activating Factor
0
Serum Albumin
0
Tumor Necrosis Factor-alpha
0
Pyruvaldehyde
722KLD7415
Glycated Serum Albumin
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Références
Toxicol Lett. 2010 Apr 1;193(3):217-23
pubmed: 20096340
Exp Mol Med. 2013 Jan 10;45:e4
pubmed: 23306702
Diabetes Care. 2010 Mar;33(3):676-82
pubmed: 20190296
Biochimie. 2011 Apr;93(4):645-58
pubmed: 21167901
Ann Clin Biochem. 2018 Nov;55(6):639-646
pubmed: 29471686
Caspian J Intern Med. 2018 Winter;9(1):71-79
pubmed: 29387323
Cell Rep. 2016 Oct 18;17(4):1022-1036
pubmed: 27760310
J Obstet Gynaecol. 2016;36(3):337-9
pubmed: 26466813
Exp Mol Med. 2009 Mar 31;41(3):208-16
pubmed: 19293640
Pediatr Res. 2012 Oct;72(4):426-31
pubmed: 22797139
Nature. 1997 Oct 9;389(6651):610-4
pubmed: 9335502
Diabetes Care. 2012 Sep;35(9):1894-6
pubmed: 22787173
Sci Rep. 2017 Jan 06;7:39904
pubmed: 28057926
Diabetes Res Clin Pract. 2015 Jan;107(1):61-8
pubmed: 25444356
J Diabetes Investig. 2010 Oct 19;1(5):202-7
pubmed: 24843433
Pediatr Neonatol. 2016 Dec;57(6):496-500
pubmed: 27131880
J Biol Chem. 1983 May 25;258(10):6142-6
pubmed: 6853480
Sci Rep. 2017 May 10;7(1):1698
pubmed: 28490763
Reprod Sci. 2009 Oct;16(10):921-37
pubmed: 19474287
J Matern Fetal Neonatal Med. 2018 Aug;31(15):2007-2012
pubmed: 28532193
Pregnancy Hypertens. 2018 Jul;13:58-61
pubmed: 30177072
Eur J Obstet Gynecol Reprod Biol. 2020 Mar;246:67-71
pubmed: 31962258
J Periodontol. 2015 Mar;86(3):387-97
pubmed: 25494659
Acta Biochim Pol. 2015;62(1):15-21
pubmed: 25781159
Hypertension. 2009 Oct;54(4):897-904
pubmed: 19687346
J Diabetes Sci Technol. 2015 Mar;9(2):169-76
pubmed: 25591856
Horm Metab Res. 2005 Jul;37(7):450-4
pubmed: 16034719
Obesity (Silver Spring). 2011 Oct;19(10):1915-22
pubmed: 21701571
Curr Diab Rep. 2018 May 9;18(6):37
pubmed: 29744612
J Biol Chem. 1997 Jan 10;272(2):971-6
pubmed: 8995390
Acta Diabetol. 2008 Sep;45(3):157-65
pubmed: 18496643
Diabetes Care. 2010 Oct;33(10):2232-7
pubmed: 20628088
Hypertension. 2017 Nov;70(5):1007-1013
pubmed: 28923901