Plausible diagnostic value of urinary isomeric dimethylarginine ratio for diabetic nephropathy.
Adult
Aged
Albuminuria
/ diagnosis
Arginine
/ analogs & derivatives
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ diagnosis
Feasibility Studies
Female
Humans
Male
Middle Aged
Predictive Value of Tests
ROC Curve
Tandem Mass Spectrometry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 02 2020
19 02 2020
Historique:
received:
14
06
2019
accepted:
23
01
2020
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Altered circulatory asymmetric and symmetric dimethylarginines have been independently reported in patients with end-stage renal failure suggesting their potential role as mediators and early biomarkers of nephropathy. These alterations can also be reflected in urine. Herein, we aimed to evaluate urinary asymmetric to symmetric dimethylarginine ratio (ASR) for early prediction of diabetic nephropathy (DN). In this cross-sectional study, individuals with impaired glucose tolerance (IGT), newly diagnosed diabetes (NDD), diabetic microalbuminuria (MIC), macroalbuminuria (MAC), and normal glucose tolerance (NGT) were recruited from Dr. Mohans' Diabetes Specialties centre, India. Urinary ASR was measured using a validated high-throughput MALDI-MS/MS method. Significantly lower ASR was observed in MIC (0.909) and MAC (0.741) in comparison to the NGT and NDD groups. On regression models, ASR was associated with MIC [OR: 0.256; 95% CI: 0.158-0.491] and MAC [OR 0.146; 95% CI: 0.071-0.292] controlled for all the available confounding factors. ROC analysis revealed ASR cut-point of 0.95 had C-statistic of 0.691 (95% CI: 0.627-0.755) to discriminate MIC from NDD with 72% sensitivity. Whereas, an ASR cut-point of 0.82 had C-statistic of 0.846 (95% CI: 0.800 - 0.893) had 91% sensitivity for identifying MAC. Our results suggest ASR as a potential early diagnostic biomarker for DN among the Asian Indians.
Identifiants
pubmed: 32076062
doi: 10.1038/s41598-020-59897-1
pii: 10.1038/s41598-020-59897-1
pmc: PMC7031402
doi:
Substances chimiques
dimethylarginine
0
symmetric dimethylarginine
49787G1ULV
Arginine
94ZLA3W45F
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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