[Lung function in the German National Cohort: methods and initial results].
Lungenfunktion in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse.
Asthma
COPD
FeNO
German National Cohort
Spirometry
Journal
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
ISSN: 1437-1588
Titre abrégé: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Pays: Germany
ID NLM: 101181368
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
pubmed:
23
2
2020
medline:
7
3
2020
entrez:
21
2
2020
Statut:
ppublish
Résumé
A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset. The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves. In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.
Sections du résumé
BACKGROUND
BACKGROUND
A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset.
MATERIAL AND METHODS
METHODS
The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves.
RESULTS
RESULTS
In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV
DISCUSSION
CONCLUSIONS
The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.
Identifiants
pubmed: 32078705
doi: 10.1007/s00103-020-03102-1
pii: 10.1007/s00103-020-03102-1
doi:
Types de publication
Journal Article
Langues
ger
Sous-ensembles de citation
IM