Effects of working memory training in patients with Parkinson's disease without cognitive impairment: A randomized controlled trial.
Aged
Cognitive Dysfunction
/ etiology
Cognitive Remediation
Feasibility Studies
Female
Follow-Up Studies
Humans
Male
Memory, Short-Term
/ physiology
Middle Aged
Outcome and Process Assessment, Health Care
Parkinson Disease
/ rehabilitation
Single-Blind Method
Therapy, Computer-Assisted
Verbal Learning
/ physiology
Non-pharmacological intervention
Parkinson's disease
Randomized controlled trial
Working memory training
Journal
Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
24
06
2019
revised:
03
02
2020
accepted:
10
02
2020
pubmed:
23
2
2020
medline:
30
1
2021
entrez:
21
2
2020
Statut:
ppublish
Résumé
To determine the feasibility and evaluate effects of a computerized working memory (WM) training (WMT) in patients with Parkinson's Disease (PD) on cognitive and clinical outcomes. 76 patients with PD without cognitive impairment were randomized to either the WMT group (n = 37), who participated in a 5-week adaptive WMT, or a passive waiting-list control group (CG, n = 39). Patients underwent clinical and neuropsychological examination at baseline, after training, and at 3-months follow-up, with verbal WM and non-verbal WM as primary outcomes. Outcome assessors were blinded for group allocation. All WMT participants completed the training successfully and reported high levels of motivation for and satisfaction with the training. Repeated-measures, linear mixed-effects models revealed positive training effects for the WMT group compared to the CG in verbal working memory with a small relative effect size 0.39 [95%CI 0.05; 0.76] for the 3-months follow-up only. No other reliable training effects in cognitive and clinical variables were found for either point of time. In this randomized controlled trial, WMT was feasible and yielded some evidence for 3-months follow-up training gains in patients with PD. WMT might be an effective intervention to prevent cognitive decline in this patient group, however, more longitudinal studies with longer follow-up periods and more sensitive assessment tools will have to proof this concept. German Clinical Trials Register (DRKS00009379).
Identifiants
pubmed: 32078917
pii: S1353-8020(20)30031-6
doi: 10.1016/j.parkreldis.2020.02.002
pii:
doi:
Banques de données
DRKS
['DRKS00009379']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-22Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest AO, KG, and SR report no disclosures. CE has received grants from the German Research Foundation (KFO219, TP 10), the Medical Faculty of the Philipps University Marburg, Germany, the German Ministry of Education and Research; honoraria from Abbvie, Wiesbaden, Germany; UCB, Monheim, Germany; Daiichi Sankyo, Munich; Medtronic, Meerbusch, Germany; Bayer Vital, Leverkusen, Germany; Bial, Mörfelden-Walldorf, Germany. PR received a travel grant from AbbVie. TvE reports having received consulting and speaker honoraria as well as research support from Siemens Healthcare, AVID Radiopharmaceuticals, Lilly, Shire Germany, Piramal (now Life Molecular Imaging) and GE Healthcare. EK has received grants from the German Ministry of Education and Research, Parkinson Fonds Deutschland gGmbH, the German Parkinson Society; honoraria from: Oticon GmbH, Hamburg, Germany; Lilly Pharma GmbH, Bad Homburg, Germany; Bernafon AG, Bern, Switzerland; Desitin GmbH, Hamburg, Germany.