Cholinesterases, α-glycosidase, and carbonic anhydrase inhibition properties of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: Synthetic analogues for the treatment of Alzheimer's disease and diabetes mellitus.

Alzheimer Disease / drug therapy Carbonic Anhydrase Inhibitors / chemistry Cholinesterase Inhibitors / chemistry Diabetes Mellitus / drug therapy Glycoside Hydrolases / antagonists & inhibitors Humans Molecular Docking Simulation Phthalazines / chemistry Pyrazoles / chemistry
10-dione 1H-pyrazolo[1, 2-b]phthalazine-5 Carbonic anhydrase Cholinesterase Molecular docking α-glycosidase

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
04 2020
Historique:
received: 06 01 2020
revised: 27 01 2020
accepted: 31 01 2020
pubmed: 23 2 2020
medline: 23 2 2021
entrez: 21 2 2020
Statut: ppublish

Résumé

In this study, using the Cu(OTf)

Identifiants

DOI: 10.1016/j.bioorg.2020.103647 PMID: 32078939
pubmed: 32078939
pii: S0045-2068(20)30037-7
doi: 10.1016/j.bioorg.2020.103647
pii:
doi:

Substances chimiques

Carbonic Anhydrase Inhibitors 0
Cholinesterase Inhibitors 0
Phthalazines 0
Pyrazoles 0
Glycoside Hydrolases EC 3.2.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103647

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Parham Taslimi (P)

Bartin University, Faculty of Science, Department of Biotechnology, 74100 Bartin, Turkey.

Kadir Turhan (K)

Yildiz Technical University, Faculty of Art and Sciences, Department of Chemistry, Davutpasa Campus, 34210 Istanbul, Turkey.

Fikret Türkan (F)

Igdır University, Health Services Vocational School, 76000 Igdır, Turkey. Electronic address: fikret.turkan@gmail.com.

Halide Sedef Karaman (H)

Atatürk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Turkey.

Zuhal Turgut (Z)

Yildiz Technical University, Faculty of Art and Sciences, Department of Chemistry, Davutpasa Campus, 34210 Istanbul, Turkey.

İlhami Gulcin (İ)

Atatürk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Turkey.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridazines › Phtalazines › Cholinesterases, α-glycosidase, and carbonic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Cholinesterases, α-glycosidase, and carbonic...