The Role of Retinoic Acid in Establishing the Early Limb Bud.
Tbx5
limb bud
limb initiation
retinoic acid
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
17 02 2020
17 02 2020
Historique:
received:
14
01
2020
revised:
12
02
2020
accepted:
13
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
18
3
2021
Statut:
epublish
Résumé
Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and specifically on the role of RA in establishing the domain of cells that will go on to form the limb itself. Although there is some consensus on the role of RA during the earliest stages of limb formation, some controversy remains on the mechanism of RA action and the requirement for RA signaling in forming the hindlimb buds.
Identifiants
pubmed: 32079177
pii: biom10020312
doi: 10.3390/biom10020312
pmc: PMC7072211
pii:
doi:
Substances chimiques
T-Box Domain Proteins
0
Tretinoin
5688UTC01R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/S000038/1
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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