Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth.

Animals Apoptosis Autoantigens / genetics Biomarkers, Tumor / genetics Cell Movement Cell Proliferation Checkpoint Kinase 1 / genetics Female Gene Expression Regulation, Neoplastic Glioblastoma / genetics Humans Intracellular Signaling Peptides and Proteins / genetics Membrane Proteins / genetics Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, Nude Mice, SCID Phosphorylation Prognosis STAT3 Transcription Factor / genetics Survival Rate Tumor Cells, Cultured Xenograft Model Antitumor Assays

Journal

Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042

Informations de publication

Date de publication:
05 2020
Historique:
received: 16 09 2019
revised: 14 01 2020
accepted: 17 02 2020
pubmed: 23 2 2020
medline: 6 3 2021
entrez: 22 2 2020
Statut: ppublish

Résumé

High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1) has been shown in glioblastoma (GBM) cell lines and in tissue sections. However, whether constitutive activation and overexpression of CHK1 in GBM plays a functional role in tumorigenesis or has prognostic significance is not known. We interrogated multiple glioma patient cohorts for expression levels of CHK1 and the oncogene cancerous inhibitor of protein phosphatase 2A (CIP2A), a known target of high-CHK1 activity, and examined the relationship between these two proteins in GBM. Expression levels of CHK1 and CIP2A were independent predictors for reduced overall survival across multiple glioma patient cohorts. Using siRNA and pharmacologic inhibitors we evaluated the impact of their depletion using both

Identifiants

DOI: 10.1158/1541-7786.MCR-19-0934 PMID: 32079743
pubmed: 32079743
pii: 1541-7786.MCR-19-0934
doi: 10.1158/1541-7786.MCR-19-0934
doi:

Substances chimiques

Autoantigens 0
Biomarkers, Tumor 0
CIP2A protein, human 0
Intracellular Signaling Peptides and Proteins 0
Membrane Proteins 0
STAT3 Transcription Factor 0
STAT3 protein, human 0
CHEK1 protein, human EC 2.7.11.1
Checkpoint Kinase 1 EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

709-722

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Anchit Khanna (A)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. jpimanda@unsw.edu.au a.khanna@unsw.edu.au.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.

Julie A I Thoms (JAI)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
School of Medical Sciences, University of New South Wales Sydney, New South Wales, Australia.
ORCID: 0000-0002-4876-7230

Brett W Stringer (BW)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Sylvia A Chung (SA)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.

Kathleen S Ensbey (KS)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Toni Rose Jue (TR)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.

Zeenat Jahan (Z)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
ORCID: 0000-0002-1738-9863

Shruthi Subramanian (S)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.

Govardhan Anande (G)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.

Han Shen (H)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
Centre for Cancer Research, Westmead Institute for Medical Research, Westmead, Australia.
Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.

Ashwin Unnikrishnan (A)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
ORCID: 0000-0001-5168-8755

Kerrie L McDonald (KL)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.

Bryan W Day (BW)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

John E Pimanda (JE)

Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. jpimanda@unsw.edu.au a.khanna@unsw.edu.au.
Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
School of Medical Sciences, University of New South Wales Sydney, New South Wales, Australia.
Department of Haematology, Prince of Wales Hospital, Randwick, New South Wales, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Checkpoint kinase 1 › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Constitutive CHK1 Expression Drives a...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Métabolisme › Phosphorylation › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Diagnostic › Pronostic › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Constitutive CHK1 Expression Drives a...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Constitutive CHK1 Expression Drives a...