Evolution of BDNF serum levels during the first six months after alcohol withdrawal.
Alcohol use disorder
BDNF
inflammation
liver function
withdrawal
Journal
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
ISSN: 1814-1412
Titre abrégé: World J Biol Psychiatry
Pays: England
ID NLM: 101120023
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
23
2
2020
medline:
28
4
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
Brain-Derived Neurotrophic Factor (BDNF) has been associated with alcohol dependence and appear to vary after withdrawal, although the link with the withdrawal outcome on the long term is unknown. We aimed to assess the evolution of BDNF levels during the six months following withdrawal and determine the association with the status of alcohol consumption. Serum BDNF levels of alcohol-dependent patients ( Abstinence decreased during follow-up and was 31.9% after six months. BDNF levels increased by 14 days after withdrawal and remained elevated throughout the six-month period, independently of alcohol consumption. Serum BDNF levels evolved over time ( A link between BDNF levels, liver function, and the inflammatory state in the context of alcohol abuse and not only with alcohol dependence itself is proposed.
Identifiants
pubmed: 32081048
doi: 10.1080/15622975.2020.1733079
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM