The BDNF Val66Met polymorphism affects negative memory bias in civilian women with PTSD.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
21
11
2019
accepted:
07
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Memory abnormalities are considered a core feature of posttraumatic stress disorder (PTSD). Studies attempting to quantify such memory dysfunction in PTSD have reported that individuals with this disorder exhibit selective memory bias toward negative material. The low expression Met allele of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with the aetiology of PTSD and with memory abnormalities. It is therefore possible that the BDNF Val66Met polymorphism can moderate the relationship between PTSD and memory bias. Here we examined this association in 50 civilian women with PTSD and 70 non-trauma-exposed healthy control women. All subjects were genotyped for the BDNF Val66Met (rs6265) polymorphism. Negative memory bias was assessed using a recognition memory task. Patients showed significantly greater negative memory bias compared to controls. In patients, negative memory bias significantly increased with increasing numbers of Met alleles; while no significant relationship was seen in controls. Further pairwise analyses revealed that patients with the Met allele had significantly greater negative memory bias than controls. These results suggest that the relationship between PTSD and negative memory bias can be moderated by the BDNF Val66Met polymorphism. More studies are needed to further clarify the relationship between this polymorphism and memory abnormalities in PTSD.
Identifiants
pubmed: 32081932
doi: 10.1038/s41598-020-60096-1
pii: 10.1038/s41598-020-60096-1
pmc: PMC7035249
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
BDNF protein, human
7171WSG8A2
Methionine
AE28F7PNPL
Valine
HG18B9YRS7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3151Références
Ehlers, A. & Clark, D. M. A cognitive model of posttraumatic stress disorder. Behav. Res. Ther. 38, 319–345 (2000).
doi: 10.1016/S0005-7967(99)00123-0
Chemtob, C. M. et al. Compelled attention: the effects of viewing trauma-related stimuli on concurrent task performance in posttraumatic stress disorder. J. Trauma. Stress 12, 309–326 (1999).
doi: 10.1023/A:1024728626505
Paunovic, N., Lundh, L. G. & Öst, L. G. Attentional and memory bias for emotional information in crime victims with acute posttraumatic stress disorder (PTSD). J. Anxiety Disord. 16, 675–692 (2002).
doi: 10.1016/S0887-6185(02)00136-6
Zeitlin, S. B. & McNally, R. J. Implicit and explicit memory bias for threat in post-traumatic stress disorder. Behav. Res. Ther. 29, 451–457 (1991).
doi: 10.1016/0005-7967(91)90129-Q
Itoh, M. et al. Memory bias and its association with memory function in women with posttraumatic stress disorder. J. Affect. Disord. 245, 461–467 (2019).
doi: 10.1016/j.jad.2018.10.365
Nees, F., Witt, S. H. & Flor, H. Neurogenetic Approaches to Stress and Fear in Humans as Pathophysiological Mechanisms for Posttraumatic Stress Disorder. Biol. Psychiatry 83, 810–820 (2018).
doi: 10.1016/j.biopsych.2017.12.015
Andero, R. & Ressler, K. J. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes Brain Behav. 11, 503–512 (2012).
doi: 10.1111/j.1601-183X.2012.00801.x
Notaras, M., Hill, R. & van den Buuse, M. The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy. Mol. Psychiatry 20, 916–930 (2015).
doi: 10.1038/mp.2015.27
Mehta, D. et al. Transcriptome analysis reveals novel genes and immune networks dysregulated in veterans with PTSD. Brain Behav. Immun. 74, 133–142 (2018).
doi: 10.1016/j.bbi.2018.08.014
Kataoka, T. et al. Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder. Genes Brain Behav. 18, e12520 (2019).
doi: 10.1111/gbb.12520
Pitts, B. L. et al. BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise. Psychoneuroendocrinology 100, 198–202 (2019).
doi: 10.1016/j.psyneuen.2018.10.011
Kunugi, H., Hori, H., Adachi, N. & Numakawa, T. Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. Psychiatry Clin. Neurosci. 64, 447–459 (2010).
doi: 10.1111/j.1440-1819.2010.02135.x
Egan, M. F. et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257–269 (2003).
doi: 10.1016/S0092-8674(03)00035-7
Notaras, M., Hill, R., Gogos, J. A. & van den Buuse, M. BDNF Val66Met genotype determines hippocampus-dependent behavior via sensitivity to glucocorticoid signaling. Mol. Psychiatry 21, 730–732 (2016).
doi: 10.1038/mp.2015.152
Notaras, M., Du, X., Gogos, J., van den Buuse, M. & Hill, R. A. The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair. Transl. Psychiatry 7, e1233 (2017).
doi: 10.1038/tp.2017.205
Soliman, F. et al. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327, 863–866 (2010).
doi: 10.1126/science.1181886
Zhang, L. et al. PTSD risk is associated with BDNF Val66Met and BDNF overexpression. Mol. Psychiatry 19, 8–10 (2014).
doi: 10.1038/mp.2012.180
Felmingham, K. L. et al. The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning. Psychoneuroendocrinology 91, 142–148 (2018).
doi: 10.1016/j.psyneuen.2018.03.002
Sohrabji, F., Miranda, R. C. & Toran-Allerand, C. D. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 92, 11110–11114 (1995).
doi: 10.1073/pnas.92.24.11110
Mahan, A. L. & Ressler, K. J. Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci. 35, 24–35 (2012).
doi: 10.1016/j.tins.2011.06.007
Jin, M. J., Jeon, H., Hyun, M. H. & Lee, S. H. Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness. Sci. Rep. 9, 6028 (2019).
doi: 10.1038/s41598-019-42563-6
Felmingham, K. L., Dobson-Stone, C., Schofield, P. R., Quirk, G. J. & Bryant, R. A. The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biol. Psychiatry 73, 1059–1063 (2013).
doi: 10.1016/j.biopsych.2012.10.033
van Oostrom, I. et al. Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women. Biol. Psychol. 89, 214–219 (2012).
doi: 10.1016/j.biopsycho.2011.10.012
Lehto, K., Mäestu, J., Kiive, E., Veidebaum, T. & Harro, J. BDNF Val66Met genotype and neuroticism predict life stress: A longitudinal study from childhood to adulthood. Eur. Neuropsychopharmacol. 26, 562–569 (2016).
doi: 10.1016/j.euroneuro.2015.12.029
Wei, S. M. et al. Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow. Cereb. Cortex 27, 2175–2182 (2017).
pubmed: 27005989
Yamaguchi-Kabata, Y. et al. iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing. Hum. Genome Var. 2, 15050 (2015).
doi: 10.1038/hgv.2015.50
Nagel, I. E. et al. Human aging magnifies genetic effects on executive functioning and working memory. Front. Hum. Neurosci. 2, 1 (2008).
doi: 10.3389/neuro.09.001.2008
Verhagen, M. et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol. Psychiatry 15, 260–271 (2010).
doi: 10.1038/mp.2008.109
Fukumoto, N. et al. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer’s disease: New data and meta-analysis. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B, 235–242 (2010).
pubmed: 19504537
Ferree, N. K., Kamat, R. & Cahill, L. Influences of menstrual cycle position and sex hormone levels on spontaneous intrusive recollections following emotional stimuli. Conscious. Cogn. 20, 1154–1162 (2011).
doi: 10.1016/j.concog.2011.02.003
Wegerer, M., Kerschbaum, H., Blechert, J. & Wilhelm, F. H. Low levels of estradiol are associated with elevated conditioned responding during fear extinction and with intrusive memories in daily life. Neurobiol. Learn. Mem. 116, 145–154 (2014).
doi: 10.1016/j.nlm.2014.10.001
Kessler, R. C., Sonnega, A., Bromet, E., Hughes, M. & Nelson, C. B. Posttraumatic stress disorder in the National Comorbidity Survey. Arch. Gen. Psychiatry 52, 1048–1060 (1995).
doi: 10.1001/archpsyc.1995.03950240066012
Stein, M. B., Jang, K. L., Taylor, S., Vernon, P. A. & Livesley, W. J. Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. Am. J. Psychiatry 159, 1675–1681 (2002).
doi: 10.1176/appi.ajp.159.10.1675
Sartor, C. E. et al. Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women. Psychol. Med. 41, 1497–1505 (2011).
doi: 10.1017/S0033291710002072
Gotoh, F. & Ohta, N. Affective valence of two-compound kanji words. Tsukuba Psychol. Res. 23, 45–52 (2001).
Nagae, N. et al. Development of the Japanese version of the Posttraumatic Diagnostic Scale: ascertaining its reliability and validity among university students. Japanese J. Trauma. Stress. 5, 51–56 (2007).
Foa, E. The Posttraumatic Diagnostic Scale (PDS) manual. (National Computer Systems, 1995).
Sheehan, D. V. et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 22–33 (1998).
pubmed: 9881538
Matsui, M., Kasai, Y. & Nagasaki, M. Reliability and validity of the Japanese version of the Repeatable Battery for the Assessment of Neuropsychological Status. Toyama Med. J. 21, 31–36 (2010).
Randolph, C., Tierney, M. C., Mohr, E. & Chase, T. N. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J. Clin. Exp. Neuropsychol. 20, 310–319 (1998).
doi: 10.1076/jcen.20.3.310.823