Advanced Glycation End Product Accumulation is Associated with Lower Cognitive Performance in an Older General Population: The Nagahama Study.
Aged
Cognition
Cognition Disorders
/ epidemiology
Cross-Sectional Studies
Educational Status
Female
Fingers
/ anatomy & histology
Fluorescence
Glycation End Products, Advanced
/ metabolism
Humans
Japan
/ epidemiology
Male
Middle Aged
Neuropsychological Tests
Psychomotor Performance
Risk Factors
Skin
Advanced glycation end products
cognitive function
epidemiological
studies
population at risk
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
23
2
2020
medline:
20
4
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
Accumulation of advanced glycation end products (AGEs) has been linked with cognitive decline as a risk factor based on the analysis in small populations. We investigated the association between skin autofluorescence of AGEs and global cognitive function in a Japanese older (≥60 years) population (n = 4,041). The AGEs quartiles were inversely associated with the Revised Hasegawa's Dementia Scale score (Q1: reference, Q2: β= -0.011, p = 0.537, Q3: β= -0.043, p = 0.016, Q4: β= -0.064, p < 0.001) independent of major risk factors. Accumulation of AGEs was associated with lower cognitive performance in older adults.
Identifiants
pubmed: 32083579
pii: JAD190878
doi: 10.3233/JAD-190878
doi:
Substances chimiques
Glycation End Products, Advanced
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM