A Generalizable Multivariate Brain Pattern for Interpersonal Guilt.
brain signature
cross-culture
fMRI
guilt
multivariate pattern analysis
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
18 05 2020
18 05 2020
Historique:
received:
01
08
2019
revised:
26
11
2019
accepted:
29
11
2019
pubmed:
23
2
2020
medline:
21
12
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
Feeling guilty when we have wronged another is a crucial aspect of prosociality, but its neurobiological bases are elusive. Although multivariate patterns of brain activity show promise for developing brain measures linked to specific emotions, it is less clear whether brain activity can be trained to detect more complex social emotional states such as guilt. Here, we identified a distributed guilt-related brain signature (GRBS) across two independent neuroimaging datasets that used interpersonal interactions to evoke guilt. This signature discriminated conditions associated with interpersonal guilt from closely matched control conditions in a cross-validated training sample (N = 24; Chinese population) and in an independent test sample (N = 19; Swiss population). However, it did not respond to observed or experienced pain, or recalled guilt. Moreover, the GRBS only exhibited weak spatial similarity with other brain signatures of social-affective processes, further indicating the specificity of the brain state it represents. These findings provide a step toward developing biological markers of social emotions, which could serve as important tools to investigate guilt-related brain processes in both healthy and clinical populations.
Identifiants
pubmed: 32083647
pii: 5735622
doi: 10.1093/cercor/bhz326
pmc: PMC7232998
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3558-3572Subventions
Organisme : NIDA NIH HHS
ID : R01 DA035484
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH076136
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116026
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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