Salinomycin Derivatives Kill Breast Cancer Stem Cells by Lysosomal Iron Targeting.
cancer stem cells
chemoselective oxidation
reactive oxygen species (ROS)
salinomycin
stereoselective reductive amination
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
10 Jun 2020
10 Jun 2020
Historique:
received:
21
01
2020
revised:
19
02
2020
pubmed:
23
2
2020
medline:
2
9
2020
entrez:
22
2
2020
Statut:
ppublish
Résumé
Salinomycin (1) exhibits a large spectrum of biological activities including the capacity to selectively eradicate cancer stem cells (CSC), making it and its derivatives promising candidates for the development of drug leads against CSC. It has been previously shown that salinomycin and its C20-propargylamine derivative (Ironomycin (2)) accumulate in lysosomes and sequester iron in this organelle. Herein, a library of salinomycin derivatives is reported, including products of C20-amination, C1-esterification, C9-oxidation, and C28-dehydration. The biological activity of these compounds is evaluated against transformed human mammary epithelial HMLER CD24
Identifiants
pubmed: 32083773
doi: 10.1002/chem.202000335
doi:
Substances chimiques
CD44 protein, human
0
Hyaluronan Receptors
0
Pyrans
0
salinomycin
62UXS86T64
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7416-7424Subventions
Organisme : H2020 European Research Council
ID : 647973
Organisme : Ligue Contre le Cancer
Organisme : Institut National de la Santé et de la Recherche Médicale
Organisme : Centre National de la Recherche Scientifique
Organisme : Fondation Charles Defforey-Institut de France
Organisme : Université de Recherche Paris Sciences et Lettres
Organisme : Labellisation Ligue Contre le Cancer
Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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