Comparison of health care resource utilization among preterm and term infants hospitalized with Human Respiratory Syncytial Virus infections: A systematic review and meta-analysis of retrospective cohort studies.
Child Health Services
/ statistics & numerical data
Delivery of Health Care
/ statistics & numerical data
Gestational Age
Hospitalization
/ statistics & numerical data
Humans
Infant
Infant, Premature
Infant, Premature, Diseases
/ therapy
Patient Acceptance of Health Care
/ statistics & numerical data
Respiratory Syncytial Virus Infections
/ therapy
Respiratory Syncytial Virus, Human
/ isolation & purification
Retrospective Studies
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
09
2019
accepted:
04
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
10
5
2020
Statut:
epublish
Résumé
Data on the variation in the medical resource utilization rate of Human Respiratory Syncytial Virus (HRSV) infected children by gestational age have recently been made available. This review aimed to determine whether prematurity is independently associated with the use of medical resources in hospitalized children for HRSV infections. We conducted this systematic review on cohort studies published on the medical resources use in preterm and full-term patients hospitalized for confirmed HRSV infections. We searched PubMed, Embase, and Global Index medicus for eligible studies. The standardized mean difference (SMD) and Risk Ratio (RR) with their 95% confidence intervals (95% CI) were estimated as summary statistics with random effects meta-analysis. The overall results were adjusted to the common confounders by stratified analyses. A total of 14 articles (20 studies) were included. Compared to full-term, preterm hospitalized with HRSV infections had more frequent intensive care unit admission (RR = 2.6, 95% CI = 1.9-3.5), increased length of stay in hospital (SMD = 0.6, 95% CI = 0.5-0.8) and intensive care unit (SMD = 0.6, 95% CI = 0.4-0.8) and increased case fatality rate (RR = 6.9, 95% CI = 2.0-23.8). Mechanical ventilation utilization was more frequent in preterm children ≤ 2 years (RR = 15.5, 95% CI = 8.9-26.4) and those who did not receive prophylaxis against HRSV (RR = 15.9, 95% CI = 9.1-27.9)] than in full-term children. No differences were identified in the frequency of emergency department visits, oxygen utilization, and the age at the first HRSV episode between preterm and full-term infants. Regardless of gestational age, preterm infants hospitalized for HRSV infections, especially those ≤ 2 years, have an increased frequency of use of health resources and poor outcomes compared to full-term infants. HRSV vaccine development programs for pregnant women should be accelerated. Review registration PROSPERO, CRD42019124375.
Identifiants
pubmed: 32084214
doi: 10.1371/journal.pone.0229357
pii: PONE-D-19-26852
pmc: PMC7034889
doi:
Types de publication
Comparative Study
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0229357Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Early Hum Dev. 2005 Sep;81(9):763-71
pubmed: 16081227
Value Health. 2003 Mar-Apr;6(2):100-6
pubmed: 12641860
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
J Glob Health. 2015 Dec;5(2):020416
pubmed: 26682048
Lancet. 2017 Sep 2;390(10098):946-958
pubmed: 28689664
Vaccine. 2019 Nov 28;37(50):7355-7362
pubmed: 28302410
Pediatrics. 2014 Aug;134(2):415-20
pubmed: 25070315
J Pediatr. 2019 Jun;209:125-129
pubmed: 30952507
Pediatrics. 1998 Sep;102(3 Pt 1):531-7
pubmed: 9738173
Eur J Pediatr. 2019 Feb;178(2):131-138
pubmed: 30610420
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Hum Immunol. 2011 Sep;72(9):708-11
pubmed: 21683109
Acta Paediatr. 2007 Apr;96(4):495-8
pubmed: 17326757
Pediatr Infect Dis J. 2014 Apr;33(4):381-6
pubmed: 24145171
Am J Perinatol. 2018 Jan;35(2):192-200
pubmed: 28881376
Am Rev Respir Dis. 1984 Apr;129(4):607-13
pubmed: 6538770
Syst Rev. 2017 Dec 06;6(1):245
pubmed: 29208034
MCN Am J Matern Child Nurs. 2009 Nov-Dec;34(6):378-84; quiz 385-6
pubmed: 19901700
J Evid Based Med. 2017 Dec 21;:
pubmed: 29266844
Expert Opin Investig Drugs. 2015;24(12):1613-30
pubmed: 26457559
Semin Perinatol. 2006 Feb;30(1):2-7
pubmed: 16549206
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
J Glob Health. 2017 Jun;7(1):010412
pubmed: 28702175
Arch Dis Child Educ Pract Ed. 2016 Feb;101(1):38-42
pubmed: 26510447
Infect Dis Ther. 2017 Dec;6(4):477-486
pubmed: 28866800
Am J Health Syst Pharm. 2016 Mar 15;73(6):405-8
pubmed: 26953285
Neonatology. 2017;111(3):240-246
pubmed: 27898422
Am J Perinatol. 2015 Sep;32(11):1017-23
pubmed: 25877742
Pediatr Infect Dis J. 2006 Dec;25(12):1188-90
pubmed: 17133170
Infect Dis Ther. 2016 Jun;5(2):125-37
pubmed: 27174177
J Formos Med Assoc. 2011 Jun;110(6):388-96
pubmed: 21741007
Adv Neonatal Care. 2017 Aug;17(4):292-298
pubmed: 27926583
Infect Dis Ther. 2016 Dec;5(4):417-452
pubmed: 27628014
J Infect Dis. 2017 Jan 1;215(1):17-23
pubmed: 27738052
J Med Econ. 2010 Mar;13(1):136-41
pubmed: 20128663
Clin Pediatr (Phila). 2015 Jun;54(6):594-7
pubmed: 25104728
Pediatr Infect Dis J. 2016 Jul;35(7):728-32
pubmed: 27078122
Early Hum Dev. 2015 Sep;91(9):541-6
pubmed: 26186560
J Pediatr. 2017 Feb;181:183-188.e1
pubmed: 27855996
Am J Dis Child. 1986 Jun;140(6):543-6
pubmed: 3706232
Am J Respir Crit Care Med. 2007 Dec 15;176(12):1269-73
pubmed: 17885265
Influenza Other Respir Viruses. 2017 Mar;11(2):122-129
pubmed: 28058797
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Pediatr Int. 2013 Jun;55(3):283-8
pubmed: 23316763
Clin Rev Allergy Immunol. 2013 Dec;45(3):331-79
pubmed: 23575961
Am J Respir Crit Care Med. 2017 Jan 1;195(1):96-103
pubmed: 27331632
Lancet. 2010 May 1;375(9725):1545-55
pubmed: 20399493
J Matern Fetal Neonatal Med. 2013 Jun;26(9):926-31
pubmed: 23379728
Pediatrics. 2010 Jul;126(1):115-28
pubmed: 20530073
J Med Econ. 2011;14(3):335-40
pubmed: 21524154
J Pediatr. 2003 Nov;143(5 Suppl):S133-41
pubmed: 14615712
PLoS One. 2009 Dec 02;4(12):e8088
pubmed: 19956576
J Pediatr. 1981 May;98(5):708-15
pubmed: 7229749
Am J Perinatol. 2020 Jan;37(2):174-183
pubmed: 31430818
Crit Care Med. 1990 Dec;18(12):1357-9
pubmed: 2245609
PLoS One. 2012;7(12):e52520
pubmed: 23300695
N Engl J Med. 2009 Feb 5;360(6):588-98
pubmed: 19196675
J Vet Intern Med. 2013 May-Jun;27(3):600-3
pubmed: 23517403
Infect Dis Ther. 2016 Sep;5(3):271-98
pubmed: 27480325
Eur J Pediatr. 2015 Apr;174(4):435-42
pubmed: 25189655
BMC Med Res Methodol. 2014 Feb 21;14:30
pubmed: 24559167