angiotensin
chronic kidney disease
epithelial sodium transport
hypertension
renal sympathetic nervous system
α2-adrenoceptor
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
17
06
2019
accepted:
30
12
2019
pubmed:
23
2
2020
medline:
11
11
2020
entrez:
23
2
2020
Statut:
ppublish
Résumé
Increased nerve activity causes hypertension and kidney disease. Recent studies suggest that renal denervation reduces BP in patients with hypertension. Renal NE release is regulated by prejunctional We investigated effects of Urinary NE excretion and BP did not differ between normotensive Our findings reveal a protective role of prejunctional inhibitory
Sections du résumé
BACKGROUND
Increased nerve activity causes hypertension and kidney disease. Recent studies suggest that renal denervation reduces BP in patients with hypertension. Renal NE release is regulated by prejunctional
METHODS
We investigated effects of
RESULTS
Urinary NE excretion and BP did not differ between normotensive
CONCLUSIONS
Our findings reveal a protective role of prejunctional inhibitory
Identifiants
pubmed: 32086277
pii: ASN.2019060599
doi: 10.1681/ASN.2019060599
pmc: PMC7191918
doi:
Substances chimiques
Receptors, Adrenergic, alpha-2
0
Angiotensin II
11128-99-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
783-798Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK083785
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098382
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK083785
Pays : United States
Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
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