Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability.

Animals Blood-Retinal Barrier / drug effects Capillary Permeability / drug effects Cattle Claudin-5 / metabolism Diabetes Mellitus, Experimental / chemically induced Eye Proteins / pharmacology Male Mitogen-Activated Protein Kinase Kinases / metabolism Rats Rats, Long-Evans Retina / metabolism Retinal Vessels / cytology Signal Transduction / drug effects Tetraspanins / genetics Up-Regulation / drug effects Vascular Endothelial Growth Factor A / pharmacology beta Catenin / antagonists & inhibitors
Wnt signaling blood-retinal barrier cell signaling diabetic retinopathy endothelium norrin permeability retina tetraspanin tetraspanin 12 (TSPAN12) tight junction vascular endothelial growth factor (VEGF)

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
03 04 2020
Historique:
received: 28 09 2019
revised: 11 02 2020
pubmed: 23 2 2020
medline: 30 12 2020
entrez: 23 2 2020
Statut: ppublish

Résumé

Vascular endothelial growth factor (VEGF) contributes to blood-retinal barrier (BRB) dysfunction in several blinding eye diseases, including diabetic retinopathy. Signaling via the secreted protein norrin through the frizzled class receptor 4 (FZD4)/LDL receptor-related protein 5-6 (LRP5-6)/tetraspanin 12 (TSPAN12) receptor complex is required for developmental vascularization and BRB formation. Here, we tested the hypothesis that norrin restores BRB properties after VEGF-induced vascular permeability in diabetic rats or in animals intravitreally injected with cytokines. Intravitreal co-injection of norrin with VEGF completely ablated VEGF-induced BRB permeability to Evans Blue-albumin. Likewise, 5-month diabetic rats exhibited increased permeability of FITC-albumin, and a single norrin injection restored BRB properties. These results were corroborated

Identifiants

DOI: 10.1074/jbc.RA119.011273 PMID: 32086377 PMC: PMC7135996
pubmed: 32086377
pii: S0021-9258(17)48726-6
doi: 10.1074/jbc.RA119.011273
pmc: PMC7135996
doi:

Substances chimiques

Claudin-5 0
Eye Proteins 0
Tetraspanins 0
Vascular Endothelial Growth Factor A 0
beta Catenin 0
Mitogen-Activated Protein Kinase Kinases EC 2.7.12.2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4647-4660

Subventions

Organisme : NEI NIH HHS
ID : R01 EY012021
Pays : United States
Organisme : NIDDK NIH HHS
ID : P60 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY007003
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL055374
Pays : United States

Informations de copyright

© 2020 Díaz-Coránguez et al.

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Auteurs

Mónica Díaz-Coránguez (M)

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105.

Cheng-Mao Lin (CM)

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105.

Stefan Liebner (S)

Institute of Neurology (Edinger Institute), University Hospital, Goethe University, 60538 Frankfurt, Germany.
ORCID: 0000-0002-4656-2258

David A Antonetti (DA)

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105 dantonet@med.umich.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Barrière hématorétinienne › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Perméabilité capillaire › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de la jonction serrée › Claudines › Claudine-5 › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Diabète expérimental › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de l'oeil › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Mitogen-Activated Protein Kinase Kinases › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Long-Evans › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Vaisseaux rétiniens › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Tétraspanines › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Norrin restores blood-retinal barrier...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Norrin restores blood-retinal barrier...