The Effects of Paclitaxel in the Combination of Diamond Nanoparticles on the Structure of Human Serum Albumin (HSA) and Their Antiproliferative Role on MDA-MB-231cells.
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Drug Combinations
Drug Synergism
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Inhibitory Concentration 50
Nanodiamonds
/ chemistry
Paclitaxel
/ chemistry
Protein Binding
Serum Albumin, Human
/ chemistry
Diamond nanoparticles (NDs)
Human serum albumin (HSA)
MDA-MB-231cells
Paclitaxel (PTX)
Spectroscopy
Zeta potential
Journal
The protein journal
ISSN: 1875-8355
Titre abrégé: Protein J
Pays: Netherlands
ID NLM: 101212092
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
23
2
2020
medline:
12
1
2021
entrez:
23
2
2020
Statut:
ppublish
Résumé
Since the interactions of anti-cancer agents with blood constituents, in particular with human serum albumin (HSA) may have a major impact on drug pharmacology, the present study designed to provide a fundamental understanding of the interaction of nanodiamonds (NDs) together with paclitaxel (PTX) with HSA in detail for the first time. The UV-Vis, steady-state fluorescence, far-UV CD and zeta potential results displayed that PTX + NDs could form a complex with HSA. Additionally, the values of binding constants and ΔG
Identifiants
pubmed: 32086692
doi: 10.1007/s10930-020-09882-4
pii: 10.1007/s10930-020-09882-4
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Drug Combinations
0
Nanodiamonds
0
Paclitaxel
P88XT4IS4D
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM