Low-dose lithium feeding increases the SERCA2a-to-phospholamban ratio, improving SERCA function in murine left ventricles.
Animals
Calcium
/ metabolism
Calcium-Binding Proteins
/ metabolism
Cardiomyopathies
/ metabolism
Glycogen Synthase Kinase 3
/ metabolism
Heart Failure
/ metabolism
Heart Ventricles
/ drug effects
Lithium
/ pharmacology
Male
Mice
Mice, Inbred C57BL
Muscle Proteins
/ metabolism
Myocytes, Cardiac
/ drug effects
Phosphorylation
/ drug effects
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/ metabolism
GSK3
SERCA
calcium
cardiac muscle
lithium supplementation
phospholamban
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
29
07
2019
accepted:
21
02
2020
pubmed:
23
2
2020
medline:
20
8
2021
entrez:
23
2
2020
Statut:
ppublish
Résumé
What is the central question of this study? Inhibition of glycogen synthase kinase-3 (GSK3) has been shown to improve cardiac SERCA2a function. Lithium can inhibit GSK3, but therapeutic doses used in treating bipolar disorder can have toxic effects. It has not been determined whether subtherapeutic doses of lithium can improve cardiac SERCA function. What is the main finding and its importance? Using left ventricles from wild-type mice, we found that subtherapeutic lithium feeding for 6 weeks decreased GSK3 activity and increased cardiac SERCA function compared with control-fed mice. These findings warrant the investigation of low-dose lithium feeding in preclinical models of cardiomyopathy and heart failure to determine the therapeutic benefit of GSK3 inhibition. The sarco(endo)plasmic reticulum Ca
Substances chimiques
Calcium-Binding Proteins
0
Muscle Proteins
0
phospholamban
0
Lithium
9FN79X2M3F
Glycogen Synthase Kinase 3
EC 2.7.11.26
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Atp2a2 protein, mouse
EC 7.2.2.10
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
666-675Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 05833
Pays : International
Organisme : NSERC Doctoral Award
Pays : International
Organisme : NSERC Undergraduate Student Research Award
Pays : International
Organisme : Brock University Explore Grant
Pays : International
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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