Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI.
Glomeruli
Olfactory bulb
Orthonasal
Retronasal
fMRI
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
08
10
2019
revised:
22
01
2020
accepted:
16
02
2020
pubmed:
23
2
2020
medline:
16
2
2021
entrez:
23
2
2020
Statut:
ppublish
Résumé
Odorants can reach olfactory receptor neurons (ORNs) by two routes: orthonasally, when volatiles enter the nasal cavity during inhalation/sniffing, and retronasally, when food volatiles released in the mouth pass into the nasal cavity during exhalation/eating. Previous work in humans has shown that both delivery routes of the same odorant can evoke distinct perceptions and patterns of neural responses in the brain. Each delivery route is known to influence specific responses across the dorsal region of the glomerular sheet in the olfactory bulb (OB), but spatial distributions across the entire glomerular sheet throughout the whole OB remain largely unexplored. We used functional MRI (fMRI) to measure and compare activations across the entire glomerular sheet in rat OB resulting from both orthonasal and retronasal stimulations of the same odors. We observed reproducible fMRI activation maps of the whole OB during both orthonasal and retronasal stimuli. However, retronasal stimuli required double the orthonasal odor concentration for similar response amplitudes. Regardless, both the magnitude and spatial extent of activity were larger during orthonasal versus retronasal stimuli for the same odor. Orthonasal and retronasal response patterns show overlap as well as some route-specific dominance. Orthonasal maps were dominant in dorsal-medial regions, whereas retronasal maps were dominant in caudal and lateral regions. These different whole OB encodings likely underlie differences in odor perception between these biologically important routes for odorants among mammals. These results establish the relationships between orthonasal and retronasal odor representations in the rat OB.
Identifiants
pubmed: 32087375
pii: S1053-8119(20)30151-8
doi: 10.1016/j.neuroimage.2020.116664
pmc: PMC9362851
mid: NIHMS1827119
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
116664Subventions
Organisme : NINDS NIH HHS
ID : P30 NS052519
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC011286
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014723
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH067528
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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