Sex Differences in Circulating Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels and Adverse Outcomes in Coronary Artery Disease.
SuPAR
biomarkers
coronary artery disease
outcomes
sex differences
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
entrez:
25
2
2020
pubmed:
25
2
2020
medline:
18
3
2021
Statut:
ppublish
Résumé
Background Women have higher circulating levels of soluble urokinase-type plasminogen activator receptor (suPAR), and elevated suPAR is associated with cardiovascular risk. The independent association of sex with suPAR and the impact of sex on its association with cardiovascular risk are unknown. Methods and Results Plasma suPAR was measured using ELISA in 2 cohorts of 666 asymptomatic individuals (49 years, 65% women) and 4184 patients with coronary artery disease (63 years, 37% women). Independent association of sex with suPAR was studied using linear regression models adjusted for demographics, risk factors, and visceral adiposity in asymptomatic participants. Impact of sex on association of suPAR with all-cause mortality was studied in patients with coronary artery disease using multivariable-adjusted Cox models. Sex-specific suPAR cutoffs for predicting all-cause mortality were calculated. Asymptomatic women had 10% higher suPAR compared with men after adjusting for confounders, and visceral adiposity partly accounted for this association. Over a median follow-up of 5.2 years, 795 deaths were recorded in patients with coronary artery disease. Log
Identifiants
pubmed: 32089048
doi: 10.1161/JAHA.119.015457
pmc: PMC7335555
doi:
Substances chimiques
PLAUR protein, human
0
Receptors, Urokinase Plasminogen Activator
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e015457Subventions
Organisme : NIA NIH HHS
ID : RF1 AG051633
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141205
Pays : United States
Organisme : NHLBI NIH HHS
ID : P20 HL113451
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS064162
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL130025
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095479
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL089650
Pays : United States
Organisme : NHLBI NIH HHS
ID : R61 HL138657
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111024
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG062334
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL086773
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL101398
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG042127
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK094346
Pays : United States
Références
J Intern Med. 2010 Sep;268(3):296-308
pubmed: 20561148
Circulation. 2004 Jun 1;109(21 Suppl 1):II2-10
pubmed: 15173056
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Circulation. 2016 Jul 26;134(4):304-13
pubmed: 27440003
Atherosclerosis. 2014 Nov;237(1):60-6
pubmed: 25222341
J Clin Endocrinol Metab. 2009 Sep;94(9):3251-8
pubmed: 19567538
PLoS One. 2014 Jun 09;9(6):e98923
pubmed: 24911522
Circulation. 2008 Nov 25;118(22):2243-51, 4p following 2251
pubmed: 18997194
Atherosclerosis. 2006 Jan;184(1):216-24
pubmed: 15993885
Eur Heart J. 2012 Oct;33(20):2551-67
pubmed: 22922414
Oncotarget. 2016 Sep 13;7(37):60206-60217
pubmed: 27517491
Science. 2006 Feb 3;311(5761):656-9
pubmed: 16456079
Circ Cardiovasc Qual Outcomes. 2017 Mar;10(3):
pubmed: 28280039
Atherosclerosis. 2017 Sep;264:108-114
pubmed: 28728756
J Am Heart Assoc. 2014 Oct 23;3(5):e001118
pubmed: 25341887
Circulation. 2016 Jan 26;133(4):361-9
pubmed: 26673559
Circ J. 2012;76(8):1958-64
pubmed: 22640984
J Am Geriatr Soc. 2010 Oct;58 Suppl 2:S298-302
pubmed: 21029057
Circulation. 2017 Feb 7;135(6):544-555
pubmed: 28153991
Elife. 2017 Aug 29;6:
pubmed: 28849762
J Pers Med. 2014 Dec 22;4(4):489-507
pubmed: 25563459
Am J Cardiol. 2012 Dec 15;110(12):1756-63
pubmed: 22981263
Postgrad Med J. 2018 Sep;94(1115):517-524
pubmed: 30177549
Nat Med. 2008 Jan;14(1):55-63
pubmed: 18084301
Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R145-51
pubmed: 17428894
Nat Med. 2017 Jan;23(1):100-106
pubmed: 27941791
Circulation. 2019 Mar 5;139(10):e56-e528
pubmed: 30700139
Immun Ageing. 2015 Aug 04;12:9
pubmed: 26244048
Int J Cardiol. 2013 Sep 10;167(6):2904-11
pubmed: 22909410
Indian J Med Res. 2017 Mar;145(3):327-333
pubmed: 28749394
N Engl J Med. 2015 Nov 12;373(20):1916-25
pubmed: 26539835
BMJ Open. 2017 Dec 29;7(12):e018753
pubmed: 29288185
Trends Immunol. 2004 Aug;25(8):450-5
pubmed: 15275645
J Am Coll Cardiol. 2013 Jul 23;62(4):329-37
pubmed: 23665099
J Am Heart Assoc. 2020 Mar 3;9(5):e015457
pubmed: 32089048
JACC Heart Fail. 2017 Apr;5(4):268-277
pubmed: 28359415
Circulation. 2019 Sep 10;140(11):e596-e646
pubmed: 30879355
Atherosclerosis. 2015 Mar;239(1):55-60
pubmed: 25574858
Cytokine. 2009 Dec;48(3):260-6
pubmed: 19758820
Nat Med. 2017 Aug;23(8):945-953
pubmed: 28650456
JAMA. 2007 Feb 14;297(6):611-9
pubmed: 17299196