NipahVR: a resource of multi-targeted putative therapeutics and epitopes for the Nipah virus.
Nipah virus
Therapeutics
Vaccine epitope
diagnostics
miRNAs
sgRNAs
siRNAs
Journal
Database : the journal of biological databases and curation
ISSN: 1758-0463
Titre abrégé: Database (Oxford)
Pays: England
ID NLM: 101517697
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
01
08
2019
revised:
20
12
2019
accepted:
23
12
2020
entrez:
25
2
2020
pubmed:
25
2
2020
medline:
20
11
2020
Statut:
ppublish
Résumé
Nipah virus (NiV) is an emerging and priority pathogen from the Paramyxoviridae family with a high fatality rate. It causes various diseases such as respiratory ailments and encephalitis and poses a great threat to humans and livestock. Despite various efforts, there is no approved antiviral treatment available. Therefore, to expedite and assist the research, we have developed an integrative resource NipahVR (http://bioinfo.imtech.res.in/manojk/nipahvr/) for the multi-targeted putative therapeutics and epitopes for NiV. It is structured into different sections, i.e. genomes, codon usage, phylogenomics, molecular diagnostic primers, therapeutics (siRNAs, sgRNAs, miRNAs) and vaccine epitopes (B-cell, CTL, MHC-I and -II binders). Most decisively, potentially efficient therapeutic regimens targeting different NiV proteins and genes were anticipated and projected. We hope this computational resource would be helpful in developing combating strategies against this deadly pathogen. Database URL: http://bioinfo.imtech.res.in/manojk/nipahvr/.
Identifiants
pubmed: 32090261
pii: 5743493
doi: 10.1093/database/baz159
pmc: PMC7036594
pii:
doi:
Substances chimiques
Antiviral Agents
0
Epitopes
0
RNA, Untranslated
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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