A single nucleotide polymorphism within HOX Transcript Antisense RNA (HOTAIR) is associated with risk of psoriasis.
HOTAIR
HOX transcript antisense RNA
lncRNA
psoriasis
rs12826786
rs1899663
rs4759314
Journal
International journal of immunogenetics
ISSN: 1744-313X
Titre abrégé: Int J Immunogenet
Pays: England
ID NLM: 101232337
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
21
12
2019
revised:
22
01
2020
accepted:
10
02
2020
pubmed:
25
2
2020
medline:
10
6
2021
entrez:
25
2
2020
Statut:
ppublish
Résumé
Recent studies have shown participation of long non-coding RNAs (lncRNAs) in the pathogenesis of psoriasis. Several mechanisms might be involved in the dysregulation of expression of lncRNAs in patients with psoriasis, among them is the presence of single nucleotide polymorphisms (SNPs) which modulate expression or function of these transcripts. In the present work, we genotyped three SNPs (rs12826786, rs1899663 and rs4759314) of the HOX Transcript Antisense RNA (HOTAIR) in 286 patients with psoriasis and 300 control subjects. The rs12826786 was associated with risk of psoriasis in dominant model (TC + TT vs. CC: OR (95% CI) = 1.59 (0.1.14-2.22), adjusted p-value = .02). In the allelic model, T allele of this SNP significantly increased the risk of psoriasis compared with the C allele (OR (95% CI) = 1.35 (1.06-1.71), adjusted p-value = .04). Other SNPs were not associated with risk of psoriasis in any inheritance model. No significant difference was found in haplotype frequencies between cases and controls. The current work shows association between a genomic variant within HOTAIR and risk of psoriasis. The clinical significance of this finding should be assessed in future studies.
Substances chimiques
HOTAIR long untranslated RNA, human
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
430-434Subventions
Organisme : Shahid Beheshti University of Medical Sciences
Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Andres, R. M., Hald, A., Johansen, C., Kragballe, K., & Iversen, L. (2013). Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity. Experimental Dermatology, 22, 323-328.
Ayala-Fontanez, N., Soler, D. C., & McCormick, T. S. (2016). Current knowledge on psoriasis and autoimmune diseases. Psoriasis (Auckl), 6, 7-32.
Barrea, L., Nappi, F., di Somma, C., Savanelli, M. C., Falco, A., Balato, A., … Savastano, S. (2016) Environmental risk factors in psoriasis: The point of view of the nutritionist. International Journal of Environmental Research and Public Health, 13(7), 743.
Dai, Y. J., Li, Y. Y., Zeng, H. M., Liang, X. A., Xie, Z. J., Zheng, Z. A., … Xing, Y. X. (2014). Effect of pharmacological intervention on MIP-1alpha, MIP-1beta and MCP-1 expression in patients with psoriasis vulgaris. Asian Pacific Journal of Tropical Medicine, 7, 582-584.
Guo, W., Dong, Z., Bai, Y., Guo, Y., Shen, S., Kuang, G., & Xu, J. (2015). Associations between polymorphisms of HOTAIR and risk of gastric cardia adenocarcinoma in a population of north China. Tumour Biology, 36, 2845-2854.
Gupta, R., Ahn, R., Lai, K., Mullins, E., Debbaneh, M., Dimon, M., … Liao, W. (2016). Landscape of long noncoding RNAs in psoriatic and healthy skin. The Journal of Investigative Dermatology, 136, 603-609.
Jiang, D. W., Xu, L., Ni, J. Q., Zhang, J., Cai, M., & Shen, L. (2019). Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer. Cancer Cell International, 19(1), 47.
Khorshidi, H. R., Taheri, M., Noroozi, R., Soudyab, M., Sayad, A., & Ghafouri-Fard, S. (2017). Investigation of the association of HOTAIR single nucleotide polymorphisms and risk of breast cancer in an iranian population. International Journal of Cancer Management, 10(5).
Li, B., Tsoi, L. C., Swindell, W. R., Gudjonsson, J. E., Tejasvi, T., Johnston, A., … Elder, J. T. (2014). Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms. The Journal of Investigative Dermatology, 134, 1828-1838.
Lizzul, P. F., Aphale, A., Malaviya, R., Sun, Y., Masud, S., Dombrovskiy, V., & Gottlieb, A. B. (2005). Differential expression of phosphorylated NF-kappaB/RelA in normal and psoriatic epidermis and downregulation of NF-kappaB in response to treatment with etanercept. The Journal of Investigative Dermatology, 124, 1275-1283.
Min, L., Mu, X., Tong, A., Qian, Y., Ling, C., Yi, T., & Zhao, X. (2018). The association between HOTAIR polymorphisms and cancer susceptibility: An updated systemic review and meta-analysis. Onco Targets and Therapy, 11, 791-800.
Obaid, M., Udden, S. M. N., Deb, P., Shihabeddin, N., Zaki, M. H., & Mandal, S. S. (2018). LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages. Scientific Reports, 8(1), 1-8.
Rajagopal, T., Talluri, S., Akshaya, R., & Dunna, N. R. (2019). HOTAIR LncRNA: A novel oncogenic propellant in human cancer. Clinica Chimica Acta, 503, 1-18. https://doi.org/10.1016/j.cca.2019.12.028
Rendon, A., & Schakel, K. (2019). Psoriasis pathogenesis and treatment. International Journal of Molecular Sciences, 20(6), 1475.
Safari, M., Noroozi, R., Taheri, M., & Ghafouri-Fard, S. (2020). The rs12826786 in HOTAIR lncRNA is associated with risk of autism spectrum disorder. Journal of Molecular Neuroscience, 70, 175-179. https://doi.org/10.1007/s12031-019-01421-w
Sirsjo, A., Karlsson, M., Gidlof, A., Rollman, O., & Torma, H. (1996). Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes. British Journal of Dermatology, 134, 643-648.
Sonkoly, E., Bata-Csorgo, Z., Pivarcsi, A., Polyanka, H., Kenderessy-Szabo, A., Molnar, G., … Szell, M. (2005). Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS. Journal of Biological Chemistry, 280, 24159-24167.
Taheri, M., Habibi, M., Noroozi, R., Rakhshan, A., Sarrafzadeh, S., Sayad, A., … Ghafouri-Fard, S. (2017). HOTAIR genetic variants are associated with prostate cancer and benign prostate hyperplasia in an Iranian population. Gene, 613, 20-24.
Tang, Q., & Hann, S. S. (2018). HOTAIR: An oncogenic long non-coding RNA in human cancer. Cellular Physiology and Biochemistry, 47, 893-913.
Tsoi, L. C., Iyer, M. K., Stuart, P. E., Swindell, W. R., Gudjonsson, J. E., Tejasvi, T., … Elder, J. T. (2015). Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin. Genome Biology, 16, 24.
Xu, F., Jin, L., Jin, Y., Nie, Z., & Zheng, H. (2019). Long noncoding RNAs in autoimmune diseases. Journal of Biomedical Materials Research Part A, 107, 468-475.
Yoo, J., Lee, Y., Kim, Y., Rha, S. Y., & Kim, Y. (2008). SNPAnalyzer 2.0: A web-based integrated workbench for linkage disequilibrium analysis and association analysis. BMC Bioinformatics, 9, 290. https://doi.org/10.1186/1471-2105-9-290