Pan-cancer mapping of differential protein-protein interactions.
Algorithms
Biomarkers, Tumor
/ metabolism
Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human
Humans
Kaplan-Meier Estimate
Neoplasm Metastasis
Neoplasms
/ metabolism
Phenotype
Principal Component Analysis
Prognosis
Protein Interaction Mapping
/ methods
Protein Interaction Maps
Transcriptome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 02 2020
24 02 2020
Historique:
received:
17
06
2019
accepted:
04
02
2020
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Deciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers. Utilizing the gene expression levels as a proxy, we have identified the differential protein-protein interactions in each cancer type and presented a differential view of human protein interactome among the cancers. We clearly demonstrate that a certain fraction of proteins differentially interacts in the cancers, but there was no general protein interactome profile that applied to all cancers. The analysis also provided the characterization of differentially interacting proteins (DIPs) representing significant changes in their interaction patterns during tumorigenesis. In addition, DIP-centered protein modules with high diagnostic and prognostic performances were generated, which might potentially be valuable in not only understanding tumorigenesis, but also developing effective diagnosis, prognosis, and treatment strategies.
Identifiants
pubmed: 32094374
doi: 10.1038/s41598-020-60127-x
pii: 10.1038/s41598-020-60127-x
pmc: PMC7039988
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3272Références
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