Mitochondrial Mechanisms in Diabetic Cardiomyopathy.
Diabetes mellitus
Diabetic cardiomyopathies
Heart failure
Mitochondria
Journal
Diabetes & metabolism journal
ISSN: 2233-6087
Titre abrégé: Diabetes Metab J
Pays: Korea (South)
ID NLM: 101556588
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
15
10
2019
accepted:
20
12
2019
entrez:
26
2
2020
pubmed:
26
2
2020
medline:
16
6
2021
Statut:
ppublish
Résumé
Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus (DM), defects in mitochondrial structure and function occur in many organs throughout the body, contributing both to the pathogenesis of DM and complications of DM. Diabetic cardiomyopathy (DbCM) is increasingly recognized as an underlying cause of increased heart failure in DM, and several mitochondrial mechanisms have been proposed to contribute to the development of DbCM. Well established mechanisms include myocardial energy depletion due to impaired adenosine triphosphate (ATP) synthesis and mitochondrial uncoupling, and increased mitochondrial oxidative stress. A variety of upstream mechanisms of impaired ATP regeneration and increased mitochondrial reactive oxygen species have been proposed, and recent studies now also suggest alterations in mitochondrial dynamics and autophagy, impaired mitochondrial Ca²⁺ uptake, decreased cardiac adiponectin action, increased O-GlcNAcylation, and impaired activity of sirtuins to contribute to mitochondrial defects in DbCM, among others. In the current review, we present and discuss the evidence that underlies both established and recently proposed mechanisms that are thought to contribute to mitochondrial dysfunction in DbCM.
Identifiants
pubmed: 32097997
pii: 44.33
doi: 10.4093/dmj.2019.0185
pmc: PMC7043970
doi:
Substances chimiques
Reactive Oxygen Species
0
Sirtuins
EC 3.5.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-53Informations de copyright
Copyright © 2020 Korean Diabetes Association.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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