PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer.
PTEN
biomarkers
breast cancer
immunohistochemistry
immunotherapy
mismatch repair
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Feb 2020
21 Feb 2020
Historique:
received:
01
02
2020
revised:
18
02
2020
accepted:
19
02
2020
entrez:
27
2
2020
pubmed:
27
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Mismatch repair (MMR) analysis in breast cancer may help to inform immunotherapy decisions but it lacks breast-specific guidelines. Unlike in other neoplasms, MMR protein loss shows intra-tumor heterogeneity and it is not mirrored by microsatellite instability in the breast. Additional biomarkers can improve MMR clinical testing. Phosphatase and tensin homolog (PTEN) inactivation is an early oncogenic event that is associated with MMR deficiency (dMMR) in several tumors. Here, we sought to characterize the diagnostic utility of PTEN expression analysis for MMR status assessment in breast cancer. A total of 608 breast cancers were profiled for their MMR and PTEN status. Proteins expression and distribution were analyzed by immunohistochemistry (IHC) on tissue microarrays and confirmed on full sections; PTEN copy number alterations were detected using a real-time PCR assay. Overall, 78 (12.8%) cases were MMR-heterogeneous (hMMR), while all patterns of PTEN expression showed no intra-tumor heterogeneity. Wild-type PTEN expression was observed in 15 (18.5%) dMMR tumors (
Identifiants
pubmed: 32098071
pii: ijms21041461
doi: 10.3390/ijms21041461
pmc: PMC7073136
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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