Influence of Geometry and Architecture on the
3D printing
bone regeneration
ceramic scaffold
demineralized bone matrix
spine fusion
Journal
Tissue engineering. Part A
ISSN: 1937-335X
Titre abrégé: Tissue Eng Part A
Pays: United States
ID NLM: 101466659
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
pubmed:
27
2
2020
medline:
16
10
2021
entrez:
27
2
2020
Statut:
ppublish
Résumé
We previously developed a recombinant growth factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This material has demonstrated the capacity to promote re-mineralization of the DBM particles within the scaffold struts and shows potential to promote successful spine fusion. Here, we investigate the role of geometry and architecture in osteointegration, vascularization, and facilitation of spine fusion in a preclinical model. Inks containing HA and DBM particles in a poly(lactide-co-glycolide) elastomer were 3D-printed into scaffolds with varying relative strut angles (90° vs. 45° advancing angle), macropore size (0 μm vs. 500 μm vs. 1000 μm), and strut alignment (aligned vs. offset). The following configurations were compared with scaffolds containing no macropores: 90°/500 μm/aligned, 45°/500 μm/aligned, 90°/1000 μm/aligned, 45°/1000 μm/aligned, 90°/1000 μm/offset, and 45°/1000 μm/offset. Eighty-four female Sprague-Dawley rats underwent spine fusion with bilateral placement of the various scaffold configurations (
Identifiants
pubmed: 32098585
doi: 10.1089/ten.TEA.2020.0004
pmc: PMC7826428
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-36Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR069580
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
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