The Phenotype of Axial Spondyloarthritis: Is It Dependent on HLA-B27 Status?
Adult
Aged
Arthritis, Psoriatic
/ diagnostic imaging
Canada
Cross-Sectional Studies
Europe
Female
HLA-B27 Antigen
/ analysis
Humans
Male
Middle Aged
Phenotype
Predictive Value of Tests
Risk Assessment
Risk Factors
Sacroiliac Joint
/ diagnostic imaging
Severity of Illness Index
Spondylitis, Ankylosing
/ diagnostic imaging
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
10
06
2019
accepted:
18
02
2020
pubmed:
27
2
2020
medline:
10
8
2021
entrez:
27
2
2020
Statut:
ppublish
Résumé
To describe the radiographic phenotype of axial spondyloarthritis (SpA) according to the presence of HLA-B27. An international collaboration compared the radiographic phenotype of axial SpA according to HLA-B27 status. Patients with ankylosing spondylitis (AS) and axial psoriatic arthritis (PsA) were collected. Radiographs were read centrally, blinded to clinical details. The symmetry of the sacroiliac joints and lumbar syndesmophytes and the morphology of syndesmophytes (typical marginal versus atypical chunky), together with the modified Stoke Ankylosing Spondylitis Spine Score and the Psoriatic Arthritis Spondylitis Radiographic Index, were recorded. A total of 244 patients with PsA and 198 patients with AS were included. In PsA, 60 patients (25%) were HLA-B27 positive while in AS, 148 patients (75%) were HLA-B27 positive. Patients with HLA-B27 were younger and more often male and had a longer duration of disease. In multivariable logistic regression, HLA-B27 was significantly associated with syndesmophyte symmetry (odds ratio [OR] 3.02 [95% confidence interval (95% CI) 1.38, 6.61]) and marginal syndesmophytes (OR 1.97 [95% CI 1.16, 3.36]) but not with sacroiliac symmetry. Mean radiographic scores were higher for patients with HLA-B27. Patients with axial SpA who are positive for HLA-B27 have more severe radiographic damage, more marginal syndesmophytes, and more frequent syndesmophyte symmetry compared to patients who are negative for HLA-B27.
Substances chimiques
HLA-B27 Antigen
0
Types de publication
Comparative Study
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
856-860Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020, American College of Rheumatology.
Références
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