Cholesterol Reduces Partitioning of Antifungal Drug Itraconazole into Lipid Bilayers.
Journal
The journal of physical chemistry. B
ISSN: 1520-5207
Titre abrégé: J Phys Chem B
Pays: United States
ID NLM: 101157530
Informations de publication
Date de publication:
19 03 2020
19 03 2020
Historique:
pubmed:
27
2
2020
medline:
15
5
2021
entrez:
27
2
2020
Statut:
ppublish
Résumé
Cholesterol plays a crucial role in modulating the physicochemical properties of biomembranes, both increasing mechanical strength and decreasing permeability. Cholesterol is also a common component of vesicle-based delivery systems, including liposome-based drug delivery systems (LDSs). However, its effect on the partitioning of drug molecules to lipid membranes is very poorly recognized. Herein, we performed a combined experimental/computational study of the potential for the use of the LDS formulation for the delivery of the antifungal drug itraconazole (ITZ). We consider the addition of cholesterol to the lipid membrane. Since ITZ is only weakly soluble in water, its bioavailability is limited. Use of an LDS has thus been proposed. We studied lipid membranes composed of cholesterol, 1-palmitoyl-2-oleoyl-
Identifiants
pubmed: 32101005
doi: 10.1021/acs.jpcb.9b11005
pmc: PMC7735721
doi:
Substances chimiques
Antifungal Agents
0
Lipid Bilayers
0
Phosphatidylcholines
0
sn-glycerol-3-phosphocholine
0
Phosphorylcholine
107-73-3
Itraconazole
304NUG5GF4
Cholesterol
97C5T2UQ7J
Glycerol
PDC6A3C0OX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2139-2148Références
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