Incorporating biological modeling into patient-specific plan verification.


Journal

Journal of applied clinical medical physics
ISSN: 1526-9914
Titre abrégé: J Appl Clin Med Phys
Pays: United States
ID NLM: 101089176

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 22 10 2019
revised: 13 01 2020
accepted: 14 01 2020
pubmed: 27 2 2020
medline: 3 2 2021
entrez: 27 2 2020
Statut: ppublish

Résumé

Dose-volume histogram (DVH) measurements have been integrated into commercially available quality assurance systems to provide a metric for evaluating accuracy of delivery in addition to gamma analysis. We hypothesize that tumor control probability and normal tissue complication probability calculations can provide additional insight beyond conventional dose delivery verification methods. A commercial quality assurance system was used to generate DVHs of treatment plan using the planning CT images and patient-specific QA measurements on a phantom. Biological modeling was performed on the DVHs produced by both the treatment planning system and the quality assurance system. The complication-free tumor control probability, P Dose measurements on a phantom can be used for pretreatment estimation of tumor control and normal tissue complication probabilities. Results in this study show how biological modeling can be used to provide additional insight about accuracy of delivery during pretreatment verification.

Identifiants

pubmed: 32101368
doi: 10.1002/acm2.12831
pmc: PMC7075379
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

94-107

Informations de copyright

© 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

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Auteurs

Ara N Alexandrian (AN)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Panayiotis Mavroidis (P)

Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA.

Ganesh Narayanasamy (G)

Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Kristen A McConnell (KA)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Christopher N Kabat (CN)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Renil B George (RB)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Dewayne L Defoor (DL)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Neil Kirby (N)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Nikos Papanikolaou (N)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

Sotirios Stathakis (S)

Department of Radiation Oncology, University of Texas Health Sciences Center, San Antonio, TX, USA.

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