Nuclear Activation Function 2 Estrogen Receptor α Attenuates Arterial and Renal Alterations Due to Aging and Hypertension in Female Mice.
Age Factors
Aging
/ genetics
Angiotensin II
Animals
Aorta, Thoracic
/ metabolism
Arterial Pressure
Disease Models, Animal
Estrogen Receptor alpha
/ deficiency
Female
Hypertension
/ chemically induced
Hypertrophy, Left Ventricular
/ etiology
Kidney
/ metabolism
Mesenteric Arteries
/ metabolism
Mice, Knockout
Nephritis
/ etiology
Vasodilation
Ventricular Function, Left
Ventricular Remodeling
aging
endothelium
estrogen
hypertension
kidney
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
entrez:
28
2
2020
pubmed:
28
2
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Background The cardiovascular protective effects of estrogens in premenopausal women depend mainly on estrogen receptor α (ERα). ERα activates nuclear gene transcription regulation and membrane-initiated signaling. The latter plays a key role in estrogen-dependent activation of endothelial NO synthase. The goal of the present work was to determine the respective roles of the 2 ERα activities in endothelial function and cardiac and kidney damage in young and old female mice with hypertension, which is a major risk factor in postmenopausal women. Methods and Results Five- and 18-month-old female mice lacking either ERα (ERα
Identifiants
pubmed: 32102616
doi: 10.1161/JAHA.119.013895
pmc: PMC7335584
doi:
Substances chimiques
Esr1 protein, mouse
0
Estrogen Receptor alpha
0
Angiotensin II
11128-99-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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