TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
01
08
2019
accepted:
29
12
2019
pubmed:
28
2
2020
medline:
24
10
2020
entrez:
28
2
2020
Statut:
ppublish
Résumé
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined TCR-peptide-HLA crystal structures and, using a single-chain peptide-HLA phage library, we generated peptide specificity profiles for three newly identified human TCRs specific for the cancer testis Ag NY-ESO-1
Identifiants
pubmed: 32102902
pii: jimmunol.1900915
doi: 10.4049/jimmunol.1900915
pmc: PMC7086387
doi:
Substances chimiques
HLA-A2 Antigen
0
Histocompatibility Antigens
0
Peptide Library
0
Peptides
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1943-1953Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
Références
PLoS One. 2018 Oct 15;13(10):e0205491
pubmed: 30321203
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15010-5
pubmed: 18809922
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Science. 1999 Oct 29;286(5441):958-61
pubmed: 10542151
Nat Protoc. 2016 Sep;11(9):1599-616
pubmed: 27490633
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
Immunity. 2003 Jan;18(1):53-64
pubmed: 12530975
BMC Bioinformatics. 2019 Jan 5;20(1):7
pubmed: 30611210
Cancer Treat Rev. 2019 Jul;77:35-43
pubmed: 31207478
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2256-68
pubmed: 15572779
Science. 2012 May 25;336(6084):1030-3
pubmed: 22628654
Nat Biotechnol. 2005 Mar;23(3):349-54
pubmed: 15723046
PLoS One. 2017 Oct 26;12(10):e0185056
pubmed: 29073143
Nucleic Acids Res. 2010 Jan;38(Database issue):D301-7
pubmed: 19900967
Annu Rev Immunol. 2015;33:169-200
pubmed: 25493333
Nat Med. 2012 Jun;18(6):980-7
pubmed: 22561687
Immunity. 2009 Dec 18;31(6):849-51
pubmed: 20064442
Immunity. 2009 Dec 18;31(6):897-908
pubmed: 20064448
Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):558-75
pubmed: 27050135
J Biol Chem. 2012 Jan 6;287(2):1168-77
pubmed: 22102287
Acta Crystallogr D Biol Crystallogr. 2006 Jan;62(Pt 1):72-82
pubmed: 16369096
Chem Biol. 2007 Aug;14(8):909-22
pubmed: 17719490
Sci Transl Med. 2013 Aug 7;5(197):197ra103
pubmed: 23926201
Nat Chem Biol. 2018 Oct;14(10):934-942
pubmed: 30224695
J Immunother. 2005 May-Jun;28(3):252-7
pubmed: 15838382
J Biol Chem. 2013 May 31;288(22):15442-54
pubmed: 23569211
J Biol Chem. 2004 May 28;279(22):23438-46
pubmed: 15004033
Nature. 1996 Nov 14;384(6605):134-41
pubmed: 8906788
Nat Commun. 2018 Mar 12;9(1):1026
pubmed: 29531227
Nat Immunol. 2016 Jan;17(1):87-94
pubmed: 26523866
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55
pubmed: 15299926
Sci Rep. 2016 Jan 13;6:18851
pubmed: 26758806
Sci Rep. 2013 Nov 06;3:3097
pubmed: 24192765
J Clin Invest. 2016 Sep 1;126(9):3626
pubmed: 27525441
Nat Biotechnol. 2001 Jan;19(1):75-8
pubmed: 11135557
J Immunol. 2000 Jul 15;165(2):948-55
pubmed: 10878370
Nature. 2017 Jul 6;547(7661):94-98
pubmed: 28636589
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
J Immunol. 2007 Nov 1;179(9):5845-54
pubmed: 17947658
J Immunol. 2017 Oct 1;199(7):2203-2213
pubmed: 28923982
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3429-33
pubmed: 1565634
Protein Eng Des Sel. 2007 Aug;20(8):397-403
pubmed: 17644531
J Immunol. 2014 Mar 15;192(6):2885-91
pubmed: 24523505
Front Immunol. 2017 Aug 07;8:935
pubmed: 28824655
J Biol Chem. 2009 Oct 2;284(40):27281-9
pubmed: 19605354
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):133-44
pubmed: 20124693
Curr Top Med Chem. 2008;8(18):1555-72
pubmed: 19075767
Protein Eng. 2003 Sep;16(9):707-11
pubmed: 14560057
Cell. 2014 May 22;157(5):1073-87
pubmed: 24855945
Methods Mol Biol. 2015;1266:171-84
pubmed: 25560075
J Immunol. 2009 Jul 1;183(1):430-7
pubmed: 19542454
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Immunity. 2011 Nov 23;35(5):681-93
pubmed: 22101157
Immunity. 1998 Apr;8(4):403-11
pubmed: 9586631
Sci Rep. 2016 Oct 13;6:35326
pubmed: 27734930
Nat Rev Immunol. 2006 Dec;6(12):883-94
pubmed: 17110956
Front Immunol. 2017 Oct 04;8:1210
pubmed: 29046675
Nat Methods. 2009 Nov;6(11):786-7
pubmed: 19876014
Nature. 2017 Jul 6;547(7661):89-93
pubmed: 28636592
Cell Rep. 2017 Apr 18;19(3):569-583
pubmed: 28423320
Annu Rev Immunol. 2006;24:419-66
pubmed: 16551255
J Exp Med. 2005 Apr 18;201(8):1243-55
pubmed: 15837811
J Immunol. 2011 Sep 1;187(5):2453-63
pubmed: 21795600