Context-Dependent Decision Making in a Premotor Circuit.
Animals
Brain Mapping
Decision Making
/ physiology
Discrimination, Psychological
/ physiology
Mice
Motor Cortex
/ physiology
Odorants
Olfactory Cortex
/ physiology
Olfactory Pathways
/ physiology
Optogenetics
Piriform Cortex
/ physiology
Psychomotor Performance
/ physiology
Pyramidal Cells
/ physiology
Reward
Smell
/ physiology
ALM
anterolateral motor cortex
context
decision-making
flexible behavior
olfaction
premotor cortex
working memory
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
22 04 2020
22 04 2020
Historique:
received:
03
09
2019
revised:
12
12
2019
accepted:
24
01
2020
pubmed:
28
2
2020
medline:
12
8
2020
entrez:
28
2
2020
Statut:
ppublish
Résumé
Cognitive capacities afford contingent associations between sensory information and behavioral responses. We studied this problem using an olfactory delayed match to sample task whereby a sample odor specifies the association between a subsequent test odor and rewarding action. Multi-neuron recordings revealed representations of the sample and test odors in olfactory sensory and association cortex, which were sufficient to identify the test odor as match or non-match. Yet, inactivation of a downstream premotor area (ALM), but not orbitofrontal cortex, confined to the epoch preceding the test odor led to gross impairment. Olfactory decisions that were not context-dependent were unimpaired. Therefore, ALM does not receive the outcome of a match/non-match decision from upstream areas. It receives contextual information-the identity of the sample-to establish the mapping between test odor and action. A novel population of pyramidal neurons in ALM layer 2 may mediate this process.
Identifiants
pubmed: 32105611
pii: S0896-6273(20)30061-1
doi: 10.1016/j.neuron.2020.01.034
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
316-328.e6Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.