Should We Consider the Cardiovascular System While Evaluating CKD-MBD?
Animals
Avitaminosis
/ epidemiology
Biomarkers
/ metabolism
Cardiovascular Diseases
/ epidemiology
Cardiovascular System
Chronic Kidney Disease-Mineral and Bone Disorder
/ epidemiology
Comorbidity
Fibroblast Growth Factor-23
Humans
Parathyroid Hormone
/ metabolism
Phosphates
/ metabolism
Risk Factors
FGF23
PTH
chronic kidney disease
klotho
left ventricular hypertrophy
phosphate
sclerostin.
uremic cardiopathy
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
25 02 2020
25 02 2020
Historique:
received:
06
01
2020
revised:
12
02
2020
accepted:
20
02
2020
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
2
3
2021
Statut:
epublish
Résumé
Cardiovascular (CV) disease is highly prevalent in the population with chronic kidney disease (CKD), where the risk of CV death in early stages far exceeds the risk of progression to dialysis. The presence of chronic kidney disease-mineral and bone disorder (CKD-MBD) has shown a strong correlation with CV events and mortality. As a non-atheromatous process, it could be partially explained why standard CV disease-modifying drugs do not provide such an impact on CV mortality in CKD as observed in the general population. We summarize the potential association of CV comorbidities with the older (parathyroid hormone, phosphate) and newer (FGF23, Klotho, sclerostin) CKD-MBD biomarkers.
Identifiants
pubmed: 32106499
pii: toxins12030140
doi: 10.3390/toxins12030140
pmc: PMC7150959
pii:
doi:
Substances chimiques
Biomarkers
0
FGF23 protein, human
0
Parathyroid Hormone
0
Phosphates
0
Fibroblast Growth Factor-23
7Q7P4S7RRE
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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