Mixed Valvular Disease Following Transcatheter Aortic Valve Replacement: Quantification and Systematic Differentiation Using Clinical Measurements and Image-Based Patient-Specific In Silico Modeling.
Aged
Aged, 80 and over
Aortic Valve Stenosis
/ complications
Echocardiography, Doppler
Female
Heart Valve Prosthesis
Humans
Male
Mitral Valve Insufficiency
/ complications
Patient-Specific Modeling
Stroke Volume
/ physiology
Transcatheter Aortic Valve Replacement
/ adverse effects
Vascular Resistance
/ physiology
Ventricular Function, Left
/ physiology
Ventricular Pressure
/ physiology
left ventricle hemodynamics
mitral regurgitation
mixed valvular disease
paravalvular leak
transcatheter aortic valve replacement
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
18
3
2021
Statut:
ppublish
Résumé
Background Mixed valvular disease (MVD), mitral regurgitation (MR) from pre-existing disease in conjunction with paravalvular leak (PVL) following transcatheter aortic valve replacement (TAVR), is one of the most important stimuli for left ventricle (LV) dysfunction, associated with cardiac mortality. Despite the prevalence of MVD, the quantitative understanding of the interplay between pre-existing MVD, PVL, LV, and post-TAVR recovery is meager. Methods and Results We quantified the effects of MVD on valvular-ventricular hemodynamics using an image-based patient-specific computational framework in 72 MVD patients. Doppler pressure was reduced by TAVR (mean, 77%; N=72;
Identifiants
pubmed: 32106747
doi: 10.1161/JAHA.119.015063
pmc: PMC7335548
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e015063Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM049039
Pays : United States
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